In Vitro ADME Assays

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Whether you're screening your first chemical series, optimizing leads, or selecting compounds for in vivo studies, our in vitro ADME testing services provide the rapid, actionable insights needed to keep your Design-Make-Test-Analyze (DMTA) cycle moving.

With fast turnaround times, direct access to experienced ADME scientists and flexible project management, we help discovery teams generate meaningful data, reduce project risk and accelerate candidate selection.

Already know what you need? Choose the option that best suits your program:

• ‍Get an instant ADME quote – Build your assay package and receive an immediate estimate.
• ‍Apply for the new client ADME focus trial – Experience our science, reporting and service before committing. ‍
• Speak to an ADME scientist – Discuss your project and develop a tailored ADME strategy.

Why in vitro ADME matters

The earlier ADME liabilities are identified, the easier and less costly they are to address. Our in vitro ADME assays help you understand absorption, metabolism, permeability and protein binding early in discovery, allowing your team to:

• Rank compounds with confidence.
• Prioritize molecules for progression.
• Support medicinal chemistry optimization.
• Predict pharmacokinetic risks earlier.
• Reduce late-stage attrition.
• Generate data to support confident go/no-go decisions.

Whether you're working within a small biotech, virtual biotech, pharmaceutical company or university spin-out, early ADME data enables smarter decisions throughout drug discovery.

Supporting every stage of the DMTA cycle

ADME and DMPK sit at the center of successful drug discovery. Our scientists work alongside your project team to ensure ADME data informs every stage of compound optimization. We help you:

• Rapidly profile new compounds.
• Build efficient ADME screening cascades.
• Interpret complex datasets.
• Prioritize compounds for progression.
• Investigate unexpected ADME liabilities.
• Support hit-to-lead and lead optimization programs.

Rather than simply generating data, we help you understand what the data means and what to do next.

Comprehensive in vitro ADME testing services

Our integrated ADME platform provides the assays needed to characterize compounds throughout discovery.

Helping you overcome common drug discovery challenges

Drug discovery programs rarely fail because of chemistry alone. Our clients come to us when they need to:

Progress promising compounds faster - Generate rapid ADME data to support medicinal chemistry decisions and maintain DMTA timelines.

Understand unexpected PK behavior - Identify metabolic liabilities and investigate issues before committing valuable resources to in vivo studies.

Extend internal capability - Access experienced ADME scientists without investing in additional in-house resource.

Keep discovery programs moving - Fast project initiation, rapid turnaround and responsive communication help prevent delays during lead optimization.

Make better progression decisions - Generate the evidence needed to confidently prioritize compounds and reduce development risk.

Why partner with Concept Life Sciences?

Choosing an ADME partner should make your project easier, not create additional complexity. At Concept Life Sciences, we've built our service around the needs of modern drug discovery teams.

Fast turnaround - Routine Tier 1 ADME assays delivered in as little as 5 working days to support rapid DMTA cycles.

Try before you commit - Choosing a new CRO is an important decision. Our ADME focus trial (FOC) allows qualifying organizations to experience our service, scientific support and data quality before committing to a larger program.

Integrated drug discovery expertise - Chemistry, biology and ADME specialists working together under one roof provide joined-up scientific insight and faster project progression.

Scientific partnership - Work directly with experienced ADME and DMPK scientists who help interpret your results, troubleshoot challenges and recommend next steps.

Flexible project management - Whether you're profiling a handful of compounds or supporting an entire lead optimization campaign, we adapt to your program as priorities change.

Simple project initiation - From straightforward compound submission to flexible call-off models and the ADME Insta-Quote Tool,  removing unnecessary administration, so you can begin generating data sooner.

Flexible reporting - Receive data in the format that works best for your team through SharePoint, email or client-specific templates.

Competitive pricing - High-quality science delivered efficiently, providing excellent value for biotech, pharmaceutical and academic drug discovery programs.

Accelerate Your ADME Project

Get Started Quickly

Whether you need a single assay or a complete in vitro ADME screening cascade, we've made it easy to start your project.

More than an outsourced ADME laboratory

As an extension of your discovery team, our scientists work collaboratively with medicinal chemists, project leaders and DMPK teams to understand program objectives, interpret results and help guide compound optimization. The result is clear, actionable ADME data that supports faster and more confident decision-making.

What our clients say

"Concept Life Sciences ADME and DMPK services supported our hit-to-lead and lead optimization programs. Their team showed great expertise and professionalism, providing invaluable insights into our compounds. The data delivered was clear and actionable, enabling us to quickly make informed decisions. Their customer service and collaboration were outstanding, with tailored approaches and prompt communication. Concept Life Sciences' ADME and DMPK services have been instrumental in our research, making them a trusted partner in drug discovery".

SVP, UK Biotech

Ready to progress your compounds with confidence?

Whether you need rapid in vitro ADME testing, support during lead optimization, or a trusted scientific partner to guide your DMTA cycle, our ADME experts are here to help. Choose the option that best suits your program:

• Get an instant ADME quote – Build your assay package and receive an immediate estimate.
• Apply for the new client ADME focus trial – Experience our science, reporting and service before committing.
• Speak to an ADME scientist – Discuss your project and develop a tailored ADME strategy.

In vitro ADME FAQs

Q: What are in vitro ADME assays used for in drug discovery?

A: In vitro ADME assays are used to evaluate how a compound is absorbed, distributed, metabolized and excreted before progressing to in vivo studies. They provide critical data on properties such as metabolic stability, permeability, solubility and protein binding, helping drug discovery teams identify promising candidates, optimize medicinal chemistry and reduce the risk of late-stage failure.

Q: When should in vitro ADME testing be performed?

A: In vitro ADME testing is typically introduced during hit-to-lead and lead optimization to support compound selection and medicinal chemistry decisions. Early ADME profiling helps identify potential liabilities, prioritize compounds for further development and generate the data needed to make informed go/no-go decisions before investing in more resource-intensive studies.

Q:  Which in vitro ADME assays are most important during lead optimization?

A: The most appropriate assays depend on your compound and therapeutic area but commonly used in vitro ADME assays include metabolic stability (microsomes and hepatocytes), plasma protein binding, permeability (Caco-2 or MDCK), solubility, CYP inhibition and induction, and plasma stability. Together, these assays provide a comprehensive understanding of compound behavior and help guide optimization strategies.

Q: How do in vitro ADME assays support the Design-Make-Test-Analyze cycle?

A: ADME and DMPK testing plays a central role in the DMTA cycle by providing rapid, actionable data that informs medicinal chemistry. Understanding ADME properties early enables scientists to refine compound design, rank candidates more effectively and accelerate progression towards candidate selection while reducing development risk.

Q: Why choose Concept Life Sciences for in vitro ADME testing?

A: Concept Life Sciences combines fast turnaround times, competitive pricing and direct access to experienced ADME scientists to help keep your drug discovery program moving. With integrated chemistry, biology and DMPK expertise under one roof, flexible project management and Tier 1 assays available in as little as five working days, we deliver clear, actionable data that supports faster decision-making and more confident compound progression.