ADMET & DMPK

Our ADMET and DMPK services streamline your drug discovery process by enabling rapid, accurate, and compound-efficient assays. With validated screening services and in vivo PK support, we ensure your programs progress swiftly and effectively.

• We deliver results quickly without comprising quality, enabling rapid progress of drug discovery programs
• Our flexible approach provides solutions to method development ensuring data is delivered efficiency
• Providing key sights from our ADMET & DMPK experts to help make informed data-driven decisions

Why ADMET & DMPK matters in drug discovery 

‍The impact of absorption, distribution, metabolism, excretion and toxicity (ADMET) properties can dramatically and negatively impact otherwise good drug activity. Conducting ADMET & DMPK studies early in the drug discovery process can minimize compound failure by: 

• Ensuring potential candidates safety profile early
• Optimizing PK parameters to ensure potential drugs reach their targets effectively
• Reducing off-target effects to improve therapeutic efficacy and safety

Later in development, ADMET and DMPK studies help validate toxicology studies, support safety evaluations prior to First-in-Human (FIH) and indicate the likelihood of drug-drug interactions. 

‍Our ADMET & DMPK services

• Validated screening services: Our in vitro ADME assays are aligned with the most recent globally recommended guidelines
• In vivo PK and bioanalysis support: We have developed a unique tiered system enabling the most time- and cost-efficient studies for your program
• Customized assays: We understand that not every molecule will fit into a standard assay format. Therefore, we develop customized assays for complex molecules. Our expertise ensures that solutions are tailored to meet your program's goals

Key benefit of partnering with us

‍Our ADMET & DMPK team emphasizes the value of time and resource at project initiation to accelerate design, make, test cycles and help make informed decisions. 

• Reducing timelines: a 5-day turnaround on routine tier 1 validated assays 
• Expert insights: Our team provides specialized knowledge to address complex challenges
• Comprehensive solutions: From routine screens to custom assays, we adapt to your needs

We are well-positioned to meet the needs of our client’s whether they require rapid data turnaround from routine screens, or customized assays for challenging molecules.