Biochemical Screening Services

We know drug discovery is complex, and early-stage screening can make or break a program.

Our biochemical screening assay services are designed to solve the key challenges teams face. By combining scientific expertise, automation, and integrated drug discovery capabilities, you will receive actionable data that enables you to drive your project forward with confident decisions.

Integrated drug discovery: from screening to clinical candidates

Biochemical screening assays find their value as primary and counter assays and are often the first critical step in your discovery cascade in early drug discovery. They are used in hit identification as a first pass, for screening potential lead compounds due to their:

• Accessibility and scalability.
• Cost-effectiveness.
• High reproducibility.
• Compatibility with automation and high-throughput screening (HTS).

By integrating screening with computational design, medicinal chemistry, ADMET/DMPK, and translational biology, we enable faster, more informed progression from target validation to development-ready candidates. This integrated drug discovery model reduces project risk, shortens development timelines, and improves candidate quality by ensuring that decisions are supported by multi-parameter data.

Addressing common challenges in biochemical screening

Drug discovery teams often face critical challenges in biochemical screening. At Concept Life Sciences we engineer solutions to solve your challenges.

Our experienced scientists proactively address risks through rigorous assay optimization, validation, and ongoing performance monitoring, ensuring the generation of reliable, decision-ready data.

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By addressing these challenges head-on, we empower your team to focus on discovering molecules with real therapeutic potential, faster and with lower risk.

Delivering integrated, reliable screening capabilities

Our biochemical assays are embedded within a full integrated drug discovery platform, combining:

• Computational design and medicinal chemistry.
• ADMET and DMPK profiling.
• Translational biology.

This means every hit from your screening cascade is evaluated in the context of potency, solubility, lipophilicity, and developability helping you make informed, risk-reduced decisions.

Assays designed for speed, reliability, and scalability

Our platforms are built to match your drug discovery pace:

Tailored assay development and optimization

We know that inconsistent assays waste time and budget. Our team optimizes every parameter, target concentration, buffers, DMSO tolerance, plate type, temperature, and incubation times so your assays perform consistently across the full screening campaign.

This robust foundation supports:

• Primary hit identification.
• Counter-screening and selectivity profiling.
• Mechanism-of-action studies.
• Potency and IC50 determination.

Integrated hit-to-lead support

Once hits are identified, by integrating screening data with ADMET and DMPK insights enables us to accelerate your candidates’ progression:

• Streamlined data workflows enable efficient rapid Design–Make–Test–Analyze (DMTA) cycles.
• Robust Structure–Activity Relationship (SAR) development.
• Continuous optimization across biology, chemistry, and DMPK disciplines.
• Selection of compounds with the best potency, solubility, and developability.

This ensures you advance the right molecules faster, reducing development timelines and risk.

Why Concept Life Sciences

Proven expertise: Multidisciplinary teams with experience across complex targets and assay formats.

Client-focused: We act as an extension of your team, interpreting data and aligning screening strategy to your goals.

Reliable data: Optimized, validated assays with ongoing performance monitoring.

Seamless integration: Biochemical screening embedded in an end-to-end discovery platform.

Scalable solutions: High-value programs delivered efficiently, whether using bespoke assays or commercial kits.

Integrated discovery platform and related services

Our biochemical screening services are embedded within our wider integrated drug discovery platform, enabling seamless progression across disciplines:

• Biophysics Screening Assays – Biophysical characterization and binding kinetics.
• Cell-Based Assays – Functional and phenotypic screening models.
• ADMET Services – In vitro and in vivo DMPK and developability assessment.
• Structural Biology - X-ray crystallography and Cryo-EM structure determination.
• Medicinal Chemistry – Hit-to-lead and lead optimization design.

Together, these services form a connected, end-to-end platform supporting target validation, hit discovery, hit-to-lead, lead optimization, and preclinical development.

Discover how our biochemical screening expertise can support your next discovery program.

Contact our team today to discuss your integrated drug discovery project requirements, biochemical screening, and hit-to-lead strategy.

Biochemical screening FAQs

Q: What types of targets can Concept Life Sciences’ biochemical screening assays handle?

A: We work with you to develop assays for a broad spectrum of targets, including enzymes, GPCRs, ion channels, nuclear receptors, epigenetic proteins, and protein–protein interactions. Whether you need commercial kits or fully customized solutions, we ensure the assay meets your project goals and accelerates decision-making.

Q: How does biochemical screening fit into an integrated drug discovery program?

A: Our biochemical screening assays are designed to deliver actionable data that directly informs your drug discovery decisions. By integrating screening with ADMET, medicinal chemistry, and cell-based assays, we help you rapidly identify promising hits, optimize leads, and reduce risks, giving you confidence at every stage.

Q: What high-throughput technologies are available for biochemical screening?

A: We provide flexible, high-throughput platforms such as HTRF, TR-FRET, NanoBRET™, AlphaLISA, FLIPR, GLO assays, rapid Westerns, and Fluorescence Polarization. These technologies are designed to handle large compound libraries efficiently, giving you reliable, fast results that keep your project on schedule.

Q: How does Concept Life Sciences ensure data quality and reproducibility in screening campaigns?

A: Your project’s success is our priority. We optimize every assay for robustness and reproducibility, use state-of-the-art ELN/LIMS systems for secure data capture, and maintain close collaboration with your team and our internal Chemistry, Biology, and ADMET experts. This ensures you receive high-quality, decision-making data you can trust.