Transcriptomics

Transcriptomics services

Seamlessly integrated with our other services in immunology, immuno-oncology, oncology, neuroscience, and spatial biology, our transcriptomic services ensure a smooth transition from your cellular assays or biopsy tissues to robust library preparation.

RNA-Sequencing library preparation

RNA-sequencing enables comprehensive analysis of gene expression across the transcriptome, helping uncover disease mechanisms, therapeutic targets, and drug resistance. The key to understanding this data is translating gene expression into biological insight. Whether you are working in discovery, diagnostics, or development our RNA-sequencing libraries are ideal for biomarker discovery, pathway analysis, and mechanistic studies. Our team can advise in selecting appropriate controls and replicates, interpret biological significance and plan follow-up validation studies (e.g. qPCR or functional assays).

Single cell transcriptomics

Single-cell technologies provide unprecedented resolution to study cellular heterogeneity, gene expression patterns, and drug responses at the individual cell level. Key applications include:

• Target identification through detailed cell subtype resolution
• Understanding biomarker expression heterogeneity
• Characterizing drug responses and mechanisms across cell types
• Selecting and validating preclinical disease models

Selection of the appropriate technology depends on the number of samples for analysis. Our scientists have over ten years’ experience in molecular biology and will guide you through selection of the best platform to suit your needs. We offer:

10X Genomics single cell transcriptomics                                      

10x Genomics’ single-cell RNA sequencing technology is the industry standard for single cell transcriptomics. Built on a microfluidics-based droplet platform, 10x Genomics enables precise encapsulation of individual cells or nuclei with barcoded beads, allowing for the generation of uniquely indexed libraries from tens of thousands of cells in a single run.

Utilizing our 10x Genomics Chromium Controller™ we can offer a diverse range of single-cell based assays including Gene Expression, Immune Profiling, and ATAC-Seq. Backed by extensive experience in processing samples for single-cell and single-nuclei analysis, our team can assist you in identifying the most appropriate assay for your research objectives.

High throughput single cell transcriptomics

For larger sample sizes, Scale Biosciences and Parse Biosciences single-cell RNA transcriptomics technologies enable high-throughput profiling of gene expression at single-cell resolution.

Using combinatorial indexing and barcoding, the platforms offers exceptional scalability and supports the use of fixed samples. Therefore, cells or nuclei—across a range of species—can be collected, fixed, frozen, and stored for later library preparation. This approach enhances workflow flexibility and the range of samples that can be collected.

With flexible kit formats, these platforms deliver the most cost-effective solutions per cell, sample, and project—ideal for both small-scale research and large-scale screening studies involving thousands of samples.