Recombinant Protein Expression, Purification and Characterization

Our Protein Science experts form part of one integrated team working alongside Structural Biologists and Biophysicists.  This wide range of expertise comes together to ensure we design, express, purify and then characterize your protein to ensure it is fit for your purpose.

Producing high quality bespoke proteins is an art form we take pride in, and we take everything into consideration.  Protein structure is central to every construct we create which we then craft further to ensure it is designed appropriately for your needs.  

Protein expression solutions

Rapidly progressing to the bench from our design consultancy, our team appropriately select the ideal protein recombinant expression host for your project.  This delivers not only active protein, but protein with the required post translational modifications coupled with offering both optimum yield and turnaround time. Experienced across challenging protein target classes, our team also offers membrane protein expertise and specializes in the production of crystallographic grade protein as a gold standard. 

Quality ensured success

Ensuring the quality of your protein is foundational to delivering success.  We offer a truly comprehensive suite of protein characterization techniques coupled with in-depth data interpretation by the biophysicists in our team.  They are happy to advise on which choice of techniques would align best with your project and provide a uniquely tailored package.

Designed to be fit-for-your-purpose – protein consultancy

• Custom protein design 
• Rapid progression from design to bench

Producing maximal soluble yields - protein expression:

• Wide choice of expression system - E.coli, Insect (Baculovirus), Mammalian or BacMam
• Toxic protein production using cell free expression
• Multi-parameter optimization screening 
• Large scale production

Purified with speed (up to crystallographic grade, 95%) - protein purification 

• Full range of chromatographic methods
• Aligned with your specific construct design for quality of purification

Quality ensured - protein characterization

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Other services related to protein science which we offer include:

• Structural biology using both X-ray crystallography and Cryo-EM approaches
• A full suite of biophysical methods
• Biochemical assay development and screening