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Immunohistochemistry and In Situ Hybridization
Understand your tissue response with tailored protein and RNA detection: from simple staining to advanced multiplex IHC and ISH
Whether you're developing a biomarker strategy, validating antibody panels, or localizing transcript expression, we offer tailored staining solutions to answer your study questions. Our immunohistochemistry (IHC) and in situ hybridization (ISH) services help you characterize tissue, identify relevant biomarkers, and understand expression patterns across healthy, diseased, and treated samples.
Explore how our expert team and state-of-the-art capabilities can integrate flexibly with your R&D processes to provide robust insight that accelerates your drug discovery and development.
By combining staining, pathology, and digital quantification under one roof, we generate the insights you need to accelerate your study, without the fragmentation, handoffs, or uncertainty of managing multiple vendors.
Our in-house expertise and integrated staining workflows offer:
- Fit-for-purpose assay design for known or novel biomarkers
- Expert guidance on marker selection, multiplex panels, and platform choice
- GCP-compliant workflows for projects requiring clinical readiness
- End-to-end support—from tissue preparation through to image analysis
Leading capabilities in IHC and ISH
Staining services
We offer a range of high-quality staining services to help you answer critical questions across preclinical and clinical programs. Services include:
- Single or dual markers chromogenic staining for protein or RNA localization
- RNA ISH for single or multiple transcript detection
- Dual stains for protein–RNA co-localization
- Multiplex protein and RNA staining to assess up to 100+ markers per tissue section
- Cutting edge multiplex staining strategies to fit any requirement
- Optimized staining protocols for FFPE, frozen tissue, cell pellet or 3D models
- Spatial transcriptomics and proteomics for in-depth molecular profiling
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Multiplexing capabilities to support complex studies
We offer a range of protein and RNA multiplexing approaches to help you localize key biomarkers and understand cell–cell interactions in complex tissue environments. Our team will work with you to choose the right panel for your targets, tissue, and research goals.
- Tailored protein panels: Bespoke assays built on primary and secondary antibody interactions
- Flexibility to include novel or custom biomarkers
- Accommodates up to 100+ markers plus nuclear counterstain
- Compatible with multiple species for broad research applications
- Options for classical primary to secondary interactions or cutting-edge barcode-based technology
- Ideal for exploratory studies or non-standard targets
- Pre-optimized protein panel: Leveraging barcode-based technology
- Panels designed to address common immuno-oncology and neurology questions
- Optimized for human tissue to ensure precision and reproducibility
- Cutting edge barcode-based technology
- Minimized optimization time for quicker turnaround
- Customized RNA + protein panels: Enabling spatial resolution of gene expression
- Spatial resolution of gene expression and protein localization
- Detect up to 6 RNA targets or 4 RNA targets with the option to co-detect 2 proteins
- Choose between chromogenic or fluorescence readouts
- Suitable for various species and adaptable to your sample type
- Enables dual readout of gene and protein expression in context
Explore More Spatial Biology Services
Our IHC and ISH services integrate seamlessly with our broader spatial biology offering:
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