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Assay Card

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Caco-2 permeability

Within the realm of drug discovery, the Caco-2 cell line, a stalwart in our scientific arsenal, takes center stage. Renowned for its prowess in in vitro permeability assessment, this immortal human colon carcinoma cell line unfolds as the quintessential model for unraveling the intricacies of drug behavior. The Caco-2 assay meticulously replicates the permeability barrier inherent in the small intestine's epithelial cell layer. A testament to its sophistication, these cells sprout microvilli on their apical surface, mirroring the nuanced morphology of gastrointestinal epithelial cells along the intestinal villi. What sets Caco-2 apart is not just its structure; it proudly boasts the expression of vital cell membrane transporters—P-glycoprotein, BCRP, and MRP2—on its apical surface. In the symphony of drug discovery, Caco-2 orchestrates a harmonious narrative, offering profound insights into permeability dynamics and paving the way for optimized drug exploration within the Concept Life Sciences ethos.

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