Digital pathology has enabled reliable and robust routine workflows for high-throughput, remote analysis of H&E and IHC stained tissue slides supporting clinical research and diagnostics. However, for complex staining protocols like multiplex immunofluorescence (mIF), no such routines are available as of now. Key challenges include heterogeneous antibody panels and difficulty generalizing algorithms across different chemistries. To address this, we present a novel end-to end workflow combining ZEISS Axioscan 7 spatial biology, Slide Stream scan automation software, and Mindpeak’s PhenoScout AI system. At the core is PhenoScout, a library of foundation AI models designed for tissue analytics across wide variety of mIF and Immunohistochemistry (IHC) stainings, requiring no prior image analysis experience.