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Powering a Decade of Organo-Electronics Innovation
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Project overview
The challenge
- The client had been facing challenges in their R&D that were hindering innovation and stalling timelines.
- Complex chemistry made exacting purity difficult to achieve.
- Sensitive, selective chemistry increased scale-up risk.
- High-quality materials were needed at pace and scale.
Our solution
- Combined synthesis, purification, analytics and scale-up expertise.
- Used Quality by Design to control key process parameters.
- Optimized crystallization and scale-up to 10L reactors.
- Developed robust procedures for sensitive chemistry.
Our impact
- Delivered 1 kg at 80% recovery and 99.91% purity.
- Met exacting purity targets, including >99.9%.
- Reduced downstream purification needs.
- Kept R&D on track with responsive scientific support.
Our team have built a >10 year partnership with a world-leading company in the organo-electronics field, growing an initial collaboration from 4 FTE to 20 FTE, supporting their R&D and manufacturing departments.
“We come to you for this compound, as no one else can make it to the same quality.”
We adapted our capabilities for active layer material analysis aligned with the clients’ needs:
“The reward for good work, is more work.”
Read on for a detailed case study below
The challenge
The client needed a long-term chemistry partner to develop and manufacture complex organo-electronics materials at high purity and scale, due to challenges in their R&D that were hindering innovation and stalling timelines.
Key challenges included impurity control, sensitive intermediates, selective chemistry and they needed a partner to synthesize active layer to the required quality, at any scale, to tight timelines.
Impurity control: Controlling for impurities in commercial starting materials.
Purification to Exacting Specification: Impurities highly structurally related.
Unstable and sensitive intermediates: Identifying and controlling critical process parameters.
Regio and chemoselectivity in key reactions: Accessing desired target with materials with multiple points of reactivity.
Bringing Reliability to Complex Chemistry: Developing processes that can be repeated and scaled up.
Our approach
Concept Life Sciences combined specialist chemistry, analytical, purification and scale-up expertise to solve the client’s material challenges.
The team used a collaborative, Quality by Design-led approach to improve control, reproducibility and transfer to larger scale.
Differentiator: Partner-level scientific engagement with rapid, proactive problem solving.
Integrated expertise: Synthesis, purification, crystallization, analytics and scale-up under one team.
Quality by Design: Critical parameters identified and controlled to access pure material.
Scale-aware development: Conditions optimized from screening to larger-scale manufacture.
Flexible chemistry: Routes, purification and methods adapted to each project challenge.
Our solution
The team converted impurity-rich starting material into a solid salt, then optimized recrystallization to remove challenging regio-isomeric impurities.
The optimized process was transferred to two 10L jacketed reactors, delivering kilogram-scale material at >99.9% purity.
Additional projects used tailored purification, controlled lithiation and selective reaction development to manage sensitive chemistry.
Methods were adapted to improve conversion, control by-products and meet client quality requirements.
Crystallization: Used Technobis Crystal16 to identify optimal solvent conditions.
Optimization: Refined solvent mix, concentration, cooling rate and crystal growth time using HEL PolyBLOCK.
Scale-up: Successfully transferred the process into 10L jacketed reactors.
Purification: Applied MDAP, SFC-prep (and analytical) reversed-phase C8/C18 plus stacked chromatography.
Lithiation: Controlled temperature, reaction time and reagent addition before 500g scale-up in a 6L ATLAS vessel.
Selectivity: Developed lithiation-bromination chemistry to access the desired regioisomer.
Reliability: Improved challenging C–N and C–O bond-forming reactions.
Quality control: Adapted analytical methods to client requirements.
The result
From complex chemistry to scalable impact
This long-term partnership shows how integrated scientific expertise, responsive collaboration and scale-aware development can turn complex chemistry into reliable, high-purity materials for advanced organo-electronics innovation.
Over more than 10 years, Concept Life Sciences - Advanced Materials team turned difficult chemistry into scalable, high-purity, deliverable materials – quickly and reliably.
Final result: High-purity active layer materials delivered to exacting specifications.
Scale: Complex chemistry advanced from development to kilogram-scale production.
R&D kept on track: With faster project timelines and responsiveness, and scalable transferable methodologies.
Enabled innovation across their pipeline: With proactive, collaborative problem solving and access to novel chemical space.
Reduced downstream purification burden: Through reliable delivery of high-quality materials.
- Met demanding specifications - 1 kg Delivered with 80% recovery and > 99.91% purity.
- Scaled sensitive chemistry to 500 g in a 6L ATLAS vessel.
- Converted inconsistent chemistry into repeatable, transferable processes.
- Reduced downstream purification through improved impurity control.
- Supported a partnership of more than 10 years, growing from 4 FTEs to a 20-FTE program.
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