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Translational Success in
Inflammasome Drug Discovery
How advanced models and integrated assays can reduce attrition
Inflammasome biology is gaining substantial momentum as chronic inflammation is recognised as a key driver across a wide spectrum of diseases, making inflammasome pathways attractive yet challenging therapeutic targets.
Despite progress in understanding targets such as NLRP3, drug developers continue to face critical hurdles around demonstrating efficacy, selectivity, and safety early in discovery, contributing to high attrition rates.
Join Professor Luke O’Neill (Trinity College Dublin) and Dr Elise Malavasi (Associate Director of Neuroscience, Concept Life Sciences) for this webinar that explores recent advances in inflammasome science, and highlights how selecting appropriate in vitro models and meaningful readouts is essential for accurately assessing therapeutic potential.
Learning objectives:
- Explore recent developments in inflammasome drug development, with particular focus on neuroscience.
- Learn how advanced in vitro assays can de-risk inflammasome-targeting programs.
When: Thursday, 21st May
- 07:00 am PST (Pacific Time - North America)
- 10:00 am EST (Eastern Time - North America)
- 4:00 pm CEST (Central European Time)
Where: Online
For more information on Inflammasome visit our Inflammsome resource hub
Professor Luke O'Neill FRS | Professor | Trinity College Dublin
Professor O’Neill, FRS is a highly respected immunologist based at Trinity College Dublin, and currently the Chair of Biochemistry, with an extensive academic track record and reputation. Professor O’Neill's current research focus is in the molecular and cellular basis to inflammation and innate immunity, toll-like receptors, pro-inflammatory cytokines, signal transduction in the immune system, and immunometabolism, acknowledged in over 460 peer reviewed publications.
Dr. Elise Malavasi | Associate Director – Neuroscience | Concept Life Sciences
Elise holds a PhD from the University of Edinburgh and brings over 15 years of experience in neuroscience research. Her academic career focused on molecular mechanisms underlying psychiatric illness and peripheral myelination, employing advanced cellular models and super-resolution microscopy to generate new insights into complex neurological processes. Since joining Concept Life Sciences in 2022, Elise has led neuroscience initiatives, shaping strategic direction, strengthening external collaborations, and driving scientific innovation across the organization.
Dr. Hayley Gooding | Biology Services Director | Concept Life Sciences
Dr. Hayley Gooding is a dedicated and enthusiastic biologist driven by the art of problem-solving and building efficient solutions. Having earned her PhD in Neuroscience from University of Edinburgh, Hayley's research provided an insight into building model systems for drug discovery and development. At Concept Life Sciences, Hayley has the privilege of leading a team of passionate scientists to deliver cutting-edge projects for the pharmaceutical and biotechnology industries.