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Synthetic Chemistry

Decades’ of leading synthetic chemistry innovations

Synthetic chemistry plays a pivotal role in successful drug discovery programmes. Designing elegant and efficient syntheses to access new chemical entities requires in-depth expertise and cutting-edge technologies. For well over 30 years, our Chemists have deployed their extensive expertise in synthesis to access unchartered chemical space and enable SAR investigations critical to our clients’ drug discovery projects.

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A more in-depth view

Fast-track drug discovery with high-end synthetic chemistry

  • > 80% of our chemists are PhD educated and have on average > 10 years’ industry experience.
  • We have a proven track record of delivering innovative syntheses with > 50 peer reviewed articles and patents authored in the last 10 years.
  • Our synthetic expertise spans across a wide range of chemistries including nucleosides, peptides, carbohydrates, macrocycles and lipids.
  • We enable SAR scouting through the efficient synthesis of classical and novel therapeutic modalities (e.g. PROTACs, ProTides, prodrugs, ADCs and covalent drugs).
  • We work in concert with drug hunters across our discovery services and are responsive to constantly evolving project needs.
  • As your project reaches key development milestones, we seamlessly transition knowhow and technologies from discovery chemistry through to kilo-scale GMP and non-GMP manufacture. 

We offer flexible synthetic chemistry services adapted to your needs, including fully integrated within our drug discovery services, synthetic and medicinal chemistry bundles or standalone synthetic chemistry.

A platform fostering innovation 

Our state-of-the-art chemistry platform empower our chemists to innovate with synthetic solutions adapted to your projects.

  • Parallel synthesis and purification for lean SAR scouting
  • Photochemistry and electrochemistry to unlock challenging synthetic routes
  • Flow chemistry and hazard evaluation to increase process safety
  • Design of Experiment (DoE) for immediate enhancement of yield and purity

Our laboratories are equipped with a comprehensive suite of instruments to analyse, purify and characterise chemical matter, with additional expertise provided by our dedicated analytical chemistry team.

  • 3 open-access 400 MHz NMRs
  • UPLC/MS and GC/MS suites
  • Mass Directed AutoPurification
  • Analytical, semi-preparative and chiral chromatography
  • Analytical and semi-preparative Supercritical Fluid Chromatography (SFC)

We pride ourselves in being at the forefront of data quality, integrity and security. All our experiments are integrated into our Scilligence ELN platform, enabling the seamless transfer of information between scientific disciplines within a project.