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Spatial Biology

How cells and molecules organise and interact within the context of the tissue environment is central to many complex biological processes, including disease progression and drug response. It is therefore crucial to study these processes within an intact tissue environment. This can be achieved using techniques that enable the visualisation and quantification of multiple biomolecules, such as RNA and protein, in situ at a single-cell level.

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A more in-depth view

In recent years the spatial biology field has taken huge strides forward, with techniques such as multiplex immunofluorescence staining, RNAscope, and spatial transcriptomics and proteomics permitting spatial phenotyping of cells across whole tissue. These techniques can be used to drive forward drug discovery by aiding with target validation, biomarker assay development, target screening, and the understanding of drug response and mechanism of action. 

We offer a range of spatial biology services to capture the varying requirements throughout the drug discovery journey.  

Histology

Our Histology team utilise the latest laboratory equipment and cutting-edge technologies to provide an end-to-end, GCP-compliant histology service from tissue sourcing and processing through to tissue staining and whole slide imaging. Key services include bespoke multiplex immunofluorescence staining and RNAscope.   

Image Analysis 

Our Image Analysis services are capable of detailed quantification of histopathology images through application of one of the leading digital pathology software currently available on the market, Visiopharm. Through use of automated algorithms, designed used artificial intelligence (AI) and deep learning, we can provide robust, reliable and replicable data on any project, from single chromogenic immunohistochemistry (IHC) staining to complex and intricate multiplex immunofluorescence (mIF) analysis on any tissue type.

Spatial Transcriptomics & Proteomics

We offer a range of spatial transcriptomics and proteomics solutions through use of the 10X Visium Spatial Gene Expression Assay and Nanostring GeoMx platform.