Photoredox Deuteration in flow

The effects of deuteration at specific positions on drug molecules has been an area of intrest for many years, with links between H-D substitution and improved pharmacokinetic properties and reduced toxicity. Additionally deuterated molecules have been utilised as reference compounds in adme-dmpk studies. The application of deuteration techniques in the process of deuterated drug production is still being developed, in 2017, Macmillan presented photoredox-catalysed methodology for deuteration of a-amino carbon atoms in APIs usingD2O. The use of flow chemistry has been shown to be a viable means for scale up of other photochemical reaction, and we herein present our attempts to investigate the effects of transferring Macmillan's chemistry to a flow paradigm.