Start your own journey to clinic

Please provide us with a few details so that we can match you with the right expert in your field.


Thank you, your request has been received.

We're busy connecting you with an expert, who will be in touch as soon as possible.

Oops! Something went wrong while submitting the form. Please try again or email us at


In a drug discovery campaign, structural biology can provide crucial insight into the mechanism of action of therapeutics and can inform subsequent cycles of the Design-Make-Test-Analyze (DMTA) cycle. At Concept Life Sciences, we provide cryogenic electron microscopy (cryoEM), which can be used to visualise macromolecules in isolation or in complex with molecular partners.

Connected servicesMore informationSpeak to an expert

Connected expertise and services

Connected expertise and services

A more in-depth view

Since cryoEM samples are prepared in solution, it is possible to solve structures of multiple states in a single sample. CryoEM is a powerful complementary technique to X-ray crystallography, as it can handle large, flexible complexes that do not typically crystallise. 

Some examples of the use of cryoEM in drug discovery are:

  • Structure determination of proteins and nucleic acids
  • Small molecule binding site analysis
  • Multi-subunit structure determination (e.g. ternary PROTAC structures)
  • Antibody epitope mapping
  • Membrane protein structure determination
  • Viral particle structure determination
  • Conformational state quantification
Connected resources