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CryoEM

In a drug discovery campaign, structural biology can provide crucial insight into the mechanism of action of therapeutics and can inform subsequent cycles of the Design-Make-Test-Analyze (DMTA) cycle. At Concept Life Sciences, we provide cryogenic electron microscopy (cryoEM), which can be used to visualise macromolecules in isolation or in complex with molecular partners.

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A more in-depth view

Since cryoEM samples are prepared in solution, it is possible to solve structures of multiple states in a single sample. CryoEM is a powerful complementary technique to X-ray crystallography, as it can handle large, flexible complexes that do not typically crystallise. 

Some examples of the use of cryoEM in drug discovery are:

  • Structure determination of proteins and nucleic acids
  • Small molecule binding site analysis
  • Multi-subunit structure determination (e.g. ternary PROTAC structures)
  • Antibody epitope mapping
  • Membrane protein structure determination
  • Viral particle structure determination
  • Conformational state quantification

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