X-ray crystallography is a powerful technique that can reveal the three-dimensional structure of proteins. It can help drug discovery programs by providing detailed information on how potential drugs interact with their target proteins at the atomic level, giving insight into the mechanism of action. This can help design and optimize drugs that have high affinity and specificity for their targets. X-ray crystallography can also be used to aid fragment-based drug discovery (FBDD) campaigns to optimize the small molecules into more effective lead compounds. At Concept Life Sciences, we have access to the UK based synchrotron facility, allowing the use of X-ray crystallography to generate target-ligand complexes.