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Investigating Polymorph Control of a potential drug substance

Polymorphs are different packing arrangements of the same molecular species. Whilst chemical characterization data will be identical, physical properties such as solubility and stability can vary significantly. The formation of different polymorphs is governed by the crystallization process solvent, temperature, cooling rate agitation and impurity profile can all have an impact. Understanding the crystallization process can improve control of polymorph formation, avoiding the need for costly process changes at later stages

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