Cure the uncurable and treat the untreatable
Few fields are as exciting as discovery chemistry. The most effective cancer therapies and ground-breaking antiviral treatments have recently emerged from the discovery chemist’s electronic laboratory notebook.
Take advantage of the latest analytical techniques and experiment with us at the edge of possibility to cure the uncurable and treat the untreatable.
Our team of forward-thinking, lightbulb-moment-creating and boundary-pushing scientists bring the latest techniques and state-of-the-art equipment to your drug discovery process.
Are you ready to explore the frontiers of the new chemical space?
When you’re working at the front-line of drug innovation it can be difficult to access the right knowledge, technology and support. As the regulatory landscape morphs to accommodate new treatment modalities, compliance becomes a moving target and it’s hard to put the right people, analysis and data together to guarantee success.
Our job is to be part of your journey to drug discovery, guiding our clients to IP generation, patent creation and publication. We believe in talking scientist-to-scientist, with dedicated points of contact and direct access to the right tools, techniques and expertise to accelerate drugs from discovery to clinic.
Beyond small molecules
We have a proven track record in progressing small molecule drug discovery programs. But that’s not all we do. Our experienced scientists use the full depth and breadth of their chemistry knowledge, along with advanced analytical instrumentation and AI techniques, to discover and progress new drug modalities, including:
- ADC synthesis
Using cutting edge bioconjugation technology
- Fragment-based drug design
With our library of ultra-small (8-16 heavy atoms) fragments we explore the edges of the lean and tractable start points for drug discovery
- Nucleotide and nucleoside discovery
We partner with some of the leading developers to deliver published and presented work, using the latest synthesis, purification, characterization and scale-up production methods
- PROTAC discovery and synthesis
Combining the benefits of small molecule drugs with gene-based knockdown
From process research and development to production
When you’re ready to take drug discovery into the development stages, we’re ready to get you from optimization to GMP manufacturing.
Discover more about our process research and development and GMP manufacturing services.
Our latest published work in discovery chemistry
Regioselective Amidomethylation of 4-Chloro-3-fluoropyridine by Metalation and Minisci-Type Reactions
Nikolaos Papaioannou, M. Jonathan Fray, Andreas Rennhack, Thomas J. Sanderson, and Jamie E. Stokes J. Org. Chem. 2020, 85, 12067-12079
Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections
Ralph Kirk, Mark Betson, Matilda Bingham, Paul Doyle, Rebecca Harvey, Anthony Huxley, John Moat, Thomas Pesnot, Michael Tait, Sebastian Hallworth, Gary Nelson, Bioorg. Med. Chem. Lett., 2020, 30, 127428