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Neurodegeneration

Neurodegenerative disorders are the leading cause of physical and cognitive disability worldwide, affecting approximately 15% of the global population. Neuroinflammation is not only a hallmark of neurodegenerative diseases, but a prominent and active contributor to disease progression. Therefore, therapeutics dampening neuroinflammation hold significant promise for the treatment of several neurodegenerative diseases. 

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A more in-depth view

We Offer a Range of Biological Models and Cutting-Edge Instrumentation to support Drug Discovery in Neuroinflammation:

  • Diverse Biological Systems: By utilising human and rodent models of increasing complexity, from cell cultures to 3D systems, we can support your drug discovery efforts.
  • A Range of Advanced Technologies: such as High-Content Imaging for in-depth phenotypic characterisation.

Our Capabilities:

  1. Inflammatory Polarisation: Evaluating microglia and astrocytes' inflammatory responses.
  2. Inflammasome Activation: Assessing activation of the inflammasome, a key component in inflammatory responses.
  3. Microglial Function: Assessing phagocytosis and migration abilities.
  4. Neurotoxicity/Neuroprotection: Determining the impact on neuronal health and function.

These approaches and capabilities collectively contribute to a comprehensive understanding of neuroinflammation and aid in developing potential treatments for neurodegenerative diseases.