The VM7Luc4E2 cell line expresses the Estrogen receptors α and β (ER α and β) and has been stably transfected with an ER-responsive luciferase reporter gene to identify chemicals that activate (agonist) or inhibit (antagonist) ER-dependent transcription.
The VM7Luc4E2 Estrogen Receptor Transactivation Assay (ERTA) is performed in agonism and/or antagonism mode, based on the OECD Guidelines for the Testing of Chemicals, Test No. 455. Cell viability is checked to enable accurate interpretation of results.
Deliverable: A Study Report will be provided in draft for customers’ comments, prior to report finalization.