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Cell Lines

Embrace the efficiency and versatility of cell line-based assays, where immortalized cell lines serve as reliable models for a wide range of applications throughout the drug discovery process.

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A more in-depth view

Advantages  of Cell Line-Based Assays:    

Consistency and Reproducibility:

  • Ensures reliability in experimental outcomes
  • High-Throughput Screening: Accelerates research by screening numerous  compounds
  • Cost-Effectiveness: Reduces costs related to experimental variability and  allows scalability
  1. Cell Line Inventory at Concept Life Sciences:  
    Instant access to a diverse inventory of cell lines representing various  cancers and tissues (e.g., skin, lung, liver, pancreas, brain).
    Ability to source cell lines from commercial vendors based on project requirements.
  2. Expertise in Tissue Culture and Assay Design:
    Skilled tissue culture and cell biologist experts to design, conduct and  interpret assays using selected methodologies and instrumentation.
    Proficient handling of multiple cell lines concurrently, ideal for substantial projects when your team's capacity is limited
  3. Work Examples Conducted Using cell lines:
    Compound Impact and Transciptomics Analysis: Assessing compound effects  on cell viability, apoptosis, and proliferation, coupled with downstream  transcriptomics analysis, beneficial for drug repositioning studies.
    Evaluation in 3D Spheroid Cultures: Comparing novel therapies in 3D  spheroid cultures versus 2D cultures for more accurate in vivo efficacy  modelling.
    Immuno-Oncology Assays: Assessing compounds for direct and indirect  impacts on cancer cell growth and metastasis through T Cell and NK  Cell-mediated tumour cell killing, efferocytosis, and phagocytosis.
    Cell Migration Assessment: Evaluating compound impact on cell migration  using assays mimicking cancer metastasis and skin epithelization, like the  Epithelial to Mesenchymal Transition assay.
    Genetic Manupulation for Target Validation: Performing genetic  manipulation to express or knock down targets for validation studies.
    CNS Function and Disease Modelling: Utilizing CNS cell lines to assess  candidate therapeutics for their ability to modulate neuroinflammatory  responses, functional phenotypes and disease-associated phenotypes

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