High-Throughput Screening: Accelerates research by screening numerous compounds
Cost-Effectiveness: Reduces costs related to experimental variability and allows scalability
Cell Line Inventory at Concept Life Sciences: Instant access to a diverse inventory of cell lines representing various cancers and tissues (e.g., skin, lung, liver, pancreas, brain). Ability to source cell lines from commercial vendors based on project requirements.
Expertise in Tissue Culture and Assay Design: Skilled tissue culture and cell biologist experts to design, conduct and interpret assays using selected methodologies and instrumentation. Proficient handling of multiple cell lines concurrently, ideal for substantial projects when your team's capacity is limited
Work Examples Conducted Using cell lines: Compound Impact and Transciptomics Analysis: Assessing compound effects on cell viability, apoptosis, and proliferation, coupled with downstream transcriptomics analysis, beneficial for drug repositioning studies. Evaluation in 3D Spheroid Cultures: Comparing novel therapies in 3D spheroid cultures versus 2D cultures for more accurate in vivo efficacy modelling. Immuno-Oncology Assays: Assessing compounds for direct and indirect impacts on cancer cell growth and metastasis through T Cell and NK Cell-mediated tumour cell killing, efferocytosis, and phagocytosis. Cell Migration Assessment: Evaluating compound impact on cell migration using assays mimicking cancer metastasis and skin epithelization, like the Epithelial to Mesenchymal Transition assay. Genetic Manupulation for Target Validation: Performing genetic manipulation to express or knock down targets for validation studies. CNS Function and Disease Modelling: Utilizing CNS cell lines to assess candidate therapeutics for their ability to modulate neuroinflammatory responses, functional phenotypes and disease-associated phenotypes