To Co-Crystal or not to co-crystal?

We’re always interested in techniques that help drug development companies turn “possible” molecules into “probable” molecules. One such technique is to co-crystallise the target molecule with a new host molecule. The hope (too much to say expectation!) is that a new physical form will be created which has better physical characteristics than the original molecule’s crystal form. Sometimes that improvement can be better solubility, or a higher melting point, or even some patent gain.

But, actually carrying out the co-crystallization experiments has often been expensive, time consuming, and the domain of specialists.

Which is why I was interested to learn of developments by some of our friends at Park Place Research ( They are about to launch a Do It Yourself kit, having identified and packaged nearly 50 potential host molecules they are preparing to offer the kit, together with “how to” instructions for drug development companies to do simple early stage – but comprehensive testing. The kit is likely to be priced at “well below £1000”.

Agenda 1 are looking to support the process, either by simple analysis of any material to see if a co-crystal has been formed, or by carrying out the experiment (for a very reasonable fee!)

The official launch and kit availability is expected shortly, I’ll announce it when it happens!