Our team is well-orchestrated in providing a lean hit-to-lead transition.

We work closely with each client to define their Target Lead Criteria and build a purposeful screening cascade allowing the efficient triage of compounds. This enables us to design and apply a strategy for the optimization of biological activity, selectivity and the pharmacokinetic profiling of screening hits.

We combine cutting-edge drug discovery tools with a lean program management ethos to deliver >2 distinct lead series matching customer-agreed Target Lead Criteria within as little as 6 months.


Our capabilities

Expeditious Design-Make-Test-Analyze cycle

  • Fast turnaround times
  • Bespoke and purposeful screening cascade
  • High-throughput biological/ADMET triage
  • Lean and flexible use of resources

Data-driven SAR optimization – every molecule counts

  • Hypothesis-driven ideation empowered by CADD
  • 96-well high-throughput synthesis platform for rapid exploration of chemical space
  • Multiparameter optimization

A comprehensive package for Lead selection

  • Continual monitoring of progress vs Target Lead Criteria
  • Early monitoring of critical toxicity endpoints
  • Ascertain in vivo PK predictions through IV/IV correlation studies
  • Regular in vivo PK studies, including relevant tissue readouts

Want to find out more?

Our multi-disciplinary teams mitigate risk by employing knowledge, foresight and thought leadership to all our client’s diverse programs enabling the highest chance of success. Get in touch to find out how we can support you.