Our team is well-orchestrated in providing a lean hit-to-lead transition.
We work closely with each client to define their Target Lead Criteria and build a purposeful screening cascade allowing the efficient triage of compounds. This enables us to design and apply a strategy for the optimization of biological activity, selectivity and the pharmacokinetic profiling of screening hits.
We combine cutting-edge drug discovery tools with a lean program management ethos to deliver >2 distinct lead series matching customer-agreed Target Lead Criteria within as little as 6 months.
Expeditious Design-Make-Test-Analyze cycle
- Fast turnaround times
- Bespoke and purposeful screening cascade
- High-throughput biological/ADMET triage
- Lean and flexible use of resources
Data-driven SAR optimization – every molecule counts
- Hypothesis-driven ideation empowered by CADD
- 96-well high-throughput synthesis platform for rapid exploration of chemical space
- Multiparameter optimization
A comprehensive package for Lead selection
- Continual monitoring of progress vs Target Lead Criteria
- Early monitoring of critical toxicity endpoints
- Ascertain in vivo PK predictions through IV/IV correlation studies
- Regular in vivo PK studies, including relevant tissue readouts