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Medicinal Chemistry

Concept Life Sciences has one of the largest chemistry groups in the UK working from state-of-the-art facilities and offering a comprehensive medicinal chemistry service to our clients.

Recognised therapeutic area expertise

Concept provides medicinal chemistry as a standalone or part of a fully integrated service which includes DMPK (in vitro, in vivo), biosciences, toxicology, API manufacture and solid state analysis. We have recognised therapeutic area expertise in areas such as immuno-oncology, neurodegeneration/regeneration, immunology and inflammation.

Over 85% of our chemists are educated to PhD level and have diverse industry experience drawn from a wide range of major pharmaceutical and biotech companies.

Our medicinal chemistry team work closely with our ADMET and in vitro biology screening teams to deliver highly efficient cycle times through the design-make-test cycle. We provide data, scientific insight and interpretation to inform the next cycle of design. We work on projects throughout the drug discovery process offering a range of services:

Hit identification and screening
Hit-to-lead
Lead optimisation
API manufacture (GMP and PR&D)
Computational chemistry support and SBDD
Parallel synthesis
Multiparameter optimisation supported by cheminformatics tools

We understand the importance of delivering against the project progression criteria and work closely with our customers to understand the competitive landscape and drug candidate proposition.

Concept scientists are viewed as true members of our partners’ project teams and we have established long-standing relationships, providing regular reporting on SAR development, LIPE progress, data trends and the evolving pharmacophore/protein docking hypothesis.

Medicinal chemistry capabilities

Multiparameter optimisation
SAR design and optimisation for HTS work up and active confirmation, hit-to-lead and lead optimisation
Fragment screening
Metabolite synthesis
Parallel synthesis
Structure based drug design

Specialist capabilities

In addition, Concept’s medicinal chemists have expertise in several specialist areas:

Bioconjugation and ADC synthesis supported by our comprehensive ADC characterisation services
PROTAC synthesis and characterisation supported by our analytical team
Compound design for diverse delivery routes oral, iv, inhaled and topical delivery programmes
Nucleotide and nucleoside projects
Natural product derived programmes
Peptidomimetic therapeutics

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Synthetic chemistry

Concept Life Sciences provides a diverse range of synthesis services to the pharmaceutical sector and academic life sciences community. Our synthetic expertise is supported by extensive analytical instrumentation and our dedicated analytical team.

Analytical chemistry

Concept Life Sciences has world leading capability in analytical services. All our chemistry labs are equipped with state-of-the-art analytical capability to support chemical synthesis, lead candidate development, and batch release testing of APIs and finished products.

Process Research and Development and Pre-clinical API Manufacture

Concept Life Sciences Process R&D team takes pride in developing scalable, innovative, safe, economical and robust processes for the manufacture of both regulated and non-regulated intermediates, registered starting materials (RSMs) and APIs (Drug Substance). We supply fit-for-purpose solutions to meet our clients’ urgent needs for the delivery of complex molecules on time and in full.