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Analytical chemistry

Concept Life Sciences has world leading capability in analytical services. All our chemistry labs are equipped with state-of-the-art analytical capability to support chemical synthesis, lead candidate development, and batch release testing of APIs and finished products.

Complex purifications and characterisation of complex molecules

Concept’s dedicated analytical team provides support for our chemistry group and our clients, in terms of optimising conditions for complex purifications and characterisation of complex molecules, as well as in process monitoring and batch release.

Our unique blend of spectroscopy, chromatography, solid state and elemental analysis provides comprehensive analytical solutions from synthetic pathway development, early lead optimisation and drug candidate selection through to PR&D, scale up and eventual GMP commercial release.

We can characterise complex biomolecules such as ADCs and can offer comprehensive assessment of drug API and drug products, where required in partnership with our sister company, Malvern Panalytical.

Our team can provide a range of outputs, from full publication-ready experimental reports to certificates of analysis, with the option of receiving raw data exports, based on customer preference.

Analytical chemistry capabilities

  • NMR
  • Prep HPLC
  • Automated purification
  • HPLC / uHPLC
  • GC
  • Counter current chromatography
  • Chiral LC
  • SFC
  • GPC / SEC
  • IR
  • Materials characterisation
  • Elemental & raw materials analysis

Our Specialist Capabilities

Separation sciences
  • HPLC / uHPLC
    • UV, PDA, DAD, Fluorescence
    • ELS, RI, CAD, MS, MS/MS
  • Gel Permeation Chromatography
  • Size Exclusion Chromatography
  • UV-directed and Mass-directed Semi and preparative HPLC
  • Gas Chromatography
    • Liquid, Headspace, Thermal desorption, Solid phase microextraction
    • Inverse GC (surface energy)
  • Ion Chromatography (anions, cations, sugars)
  • High Res MS (EI, FAB source), Elemental (CHN) analysis
  • Chiral separations
  • Counter current chromatography
  • Supercritical fluid chromatography
  • Thin layer chromatography
  • Dissolution

Materials characterisation

  • Fully automated high-resolution multinuclear NMR
  • X-Ray powder diffraction, Single crystal-XRD
  • Particle analysis using the Malvern Panalytical Morpholgi4-ID:
    • Static imaging
    • Automated shape analysis
    • Component specific Morphologically Directed Raman Spectroscopy (MDRS)
  • Particle size determination:
    • Malvern Mastersizer 2000 & 3000 Laser Diffraction, with Hydro MV, SM, S, Sirocco and AERO Dosing Units
    • Malvern Zetasizer Ultra and Nano S Dynamic Light Scattering
    • Sympatec HELOS / RODOS with VIBRI, ASPIROS and CUVETTE Dosing Units
    • Sieving / Sieve Shaker
  • Specific Surface Area analysis – BET and Porosity
  • Thermogravimetric Analysis / Differential Scanning Calorimetry / Modulated DSC / Hyper DSC
  • Isothermal Calorimetry
  • Dynamic Vapour Sorption
  • Optical microscopy / Scanning Electron Microscopy
  • Rheology:
    • Viscosity profiling (pseudoplasticity / dilatancy)
    • Yield stress determination
    • Viscoelastic behaviour determination (G’, G’’, phase angle)
    • Thixotropy assessments
    • Monitoring of curing processes
    • Axial testing
    • Dynamic Mechanical Analysis (DMA) of solid samples

Elemental and raw materials analysis

  • Inductively Plasma – Optical Emission Spectroscopy / Mass Spectrometry
  • Scanning Electron Microscopy – Energy Dispersive X-Ray analysis
  • MgSt surface coverage (SEM-EDX & ToF-SIMS)
  • NMR (to 700MHz)
  • Fourier Transform Infra-Red spectroscopy (FTIR)
  • UV-Vis Spectrophotometry
  • Viscosity, Density
  • Loss on Ignition / Loss on Drying / Residue on Evaporation
  • Sulphated ash / USP <231> Heavy metals
  • Total Organic Carbon
  • Melting point / pH / Conductivity
  • Manual and Autotitration, Karl Fischer analysis
    • Coulometric
    • Volumetric
    • Oven
  • Pharmaceutical microbiology
    • Bioburden (TVC, TYMC, TAMC, specified organisms, MLT)
    • Antimicrobial Effectiveness Test (AET)
    • Preservative Efficacy Test (PET)
    • Sterility
    • Biopotency
    • Endotoxins

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Medicinal chemistry

Concept Life Sciences has one of the largest chemistry groups in the UK working from state-of-the-art facilities and offering a comprehensive medicinal chemistry service to our clients.

Synthetic chemistry

Concept Life Sciences provides a diverse range of synthesis services to the pharmaceutical sector and academic life sciences community. Our synthetic expertise is supported by extensive analytical instrumentation and our dedicated analytical team.

Process Research and Development and Pre-clinical API Manufacture

Concept Life Sciences Process R&D team takes pride in developing scalable, innovative, safe, economical and robust processes for the manufacture of both regulated and non-regulated intermediates, registered starting materials (RSMs) and APIs (Drug Substance). We supply fit-for-purpose solutions to meet our clients’ urgent needs for the delivery of complex molecules on time and in full.