Our expert biology team offers a variety of discovery, preclincial and clinical research services. This includes validated biomarker assays, utilising multiplex readout technologies such as MSD’s MESO QuickPlex SQ120 for rapid highly-sensitive results and Akoya Biosciences® Vectra® Polaris™ Automated Quantitative Pathology Imaging System. This allows us to create stunning high-quality fluorescent images of multiple biomarkers on a single section. Up to nine markers (8 + DAPI) (9-plex) can be visualised at 10-40x, allowing for image analysis, quantification and phenotyping of samples.
We also offer multi-colour flow cytometry, ELISA and Luminex®. Our highly experienced immunologists are able to deliver a wide range of customisable multiplex analyses of protein biomarkers. Our multiplex approaches can be used to stratify patient response to therapy, supporting our client’s specific biomarker strategy from discovery through to clinic.
For those protein biomarkers which do not have suitable reagents, our specialist bioanalytical team can also provide LC-MS/MS based support. This is delivered through either intact analysis via high resolution accurate mass, or the gold standard surrogate peptide approach via more traditional quantitative LC-MS/MS techniques.