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Discovery bioanalysis

Concept Life Sciences' highly experienced scientists work closely with you to ensure appropriate bioanalytical techniques are used to maximise data generation and ensure your timelines are met.

Tailored Bioanalytical requirements to support your studies

We tailor bioanalytical requirements to support your studies depending on what data is prescribed. This may include limit of quantification, potential distribution into tissues or retrospective metabolite profiling (use of High-Resolution Accurate Mass).

If needed, we can rapidly perform method feasibility studies to provide an indication of how complex a bioanalytical method may need to be to support the in vivo study. Alternatively, such feasibility studies can help drive the in vivo design to ensure all necessary data can be collected without bioanalytical limitations.

Discovery bioanalytical services
  • Rapid PK studies
  • ‘Cold’ Tissue Distribution support
  • Method Feasibility if required
  • Application of High-Resolution Accurate Mass technology for retrospective data mining.
  • PK data analysis (WinNonlin) available
  • Microsampling techniques (DBS, CMS, VAMS and Blood/Water) fully supported
Instrumentation and techniques
  • Sciex 6500 and Waters TQS Triple Quadrupoles
  • Sciex QTrap® 6500+ with MRM3 capability for enhanced specificity
  • Waters GS-XS QTof for High Resolution Accurate Mass
  • SelexION™ differential ion mobility technology for increased specificity
  • 2D-ExionLC with multi-dimensional chromatography for increased selectivity
  • On-line radiochemical detection, UV, and GC-MS/FID for analytical support of compounds not amenable to LC-MS/MS
  • Chiral Chromatography
  • Metabolite and multi-analyte methodologies
  • Surrogate peptide approaches in support of large molecule bioanalysis by LC-MS/MS (Proteins, ADCs, etc.)
  • Oligonucleotide analysis

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