In Vivo ADME

Concept Life Science’s in vivo ADME scientists engage with clients to help design the most appropriate study format tailored to our clients' requirements. In life phases are delivered through our trusted partners and the samples are then returned to Concept Life Sciences for bioanalytical, biotransformation or histological assessments.

Highest industry standards

From early discovery activities through to GLP TK studies, Concept Life Science’s in vivo ADME team supports projects from inception to final report. Our services include client consultation at project outset, preparation of protocols and project management of both internal and external activities. We work to the highest industry standards and strict acceptance criteria to ensure our data is of the high quality.

Our discovery ADME and bioanalytical labs are capable of rapid method development for early stage PK studies and ‘cold’ tissue distribution studies (cross link to Discovery BioA page) whilst our regulatory bioanalytical laboratories are GLP accredited and as such have the capability to develop and validated fully compliant methodologies (cross link to preclinical BioA page) in support of GLP TK studies.

In addition to bioanalytical determinations, our labs also support biomarker (cross link to Biomarker page) assays and in vivo Biotransformation (cross link to Met ID page). Concentration data is also further processed to provide pharmaco and toxicokinetic information using industry standard Phoenix WinNonLin software.

By understanding the project and client needs as fully as possible, our in vivo ADME scientists the most appropriate approaches and experiments. Our experience allows us to take a logical approach to novel assay development and troubleshooting, engaging with clients frequently throughout the assay development process.

In vivo ADME capabilities

  • Bioanalytical method development and validation
  • Determination of PK/TK parameters
  • Microsampling PK capabilities (DBS, CMS, VAMS and Blood:Water)
  • Bile duct cannulated studies
  • Organ distribution
  • Brain distribution and CSF sampling
  • In vivo metabolism

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In Vitro ADME screening

Concept Life Science’s in vitro ADME team has significant expertise in a wide range of screening experiments, appreciate the need for rapid sample turn around, and provide high quality data.

Metabolite Profiling and Identification

With over 60 years’ experience in biotransformation, Concept Life Sciences is the partner to support all your metabolite profiling and identification requirements. From eliminating metabolic ‘soft spots’ in support of early stage discovery activities to first in human/patient clinical studies to ensure in all in vivo human metabolites have safety coverage, our team has significant expertise in designing and interpretation of biotransformation data.

Toxicology

Concept Life Sciences is a leading provider of predictive, mechanistic and investigative pharmacology and toxicology solutions to the pharmaceutical and biotechnology industries.