Concept Life Science’s in vitro ADME team has significant expertise in a wide range of screening experiments, appreciate the need for rapid sample turn around, and provide high quality data.
Concept Life Sciences offers a wide range of in vitro screens to support the early assessment of compounds. These services include test item characterisation, as well as an evaluation of physiochemical properties, permeability, tissue binding, metabolism, and drug-drug interactions.
Our teams work collaboratively with clients to select or customise suitable experiments in order to appropriately characterise compounds and we have the capability to run in vitro assays to regulatory standards where required.
Liquid chromatography/tandem mass spectrometry is often our most commonly used method of quantitative analysis, however, for those classes of compound not amenable to LC-MS/MS, we can also support liquid chromatography with UV or radio chemical detection and gas chromatography with mass spectrometric or flame ionisation detection.
Our liquid handling and automated data management systems support high compound throughput, enabling us to partner with clients to accelerate discovery programs. We can commit to ongoing programs of work and support regular routine screens with timely data delivery.
We also understand that some challenging classes of compounds are not always suited to automated high throughput screening and may require additional controls and considerations.
For these instances we have the capability to work under red light, in closed systems, or in glassware (thus minimising non-specific compound binding to plastics).
In addition to small molecule evaluation, we offer services for quantification and characterisation of peptide and protein biotherapeutics. We have established methodology for the absolute quantification of peptides and, by the surrogate peptide method, proteins by LC-MS/MS. This can be applied in a variety of biological matrices.