Concept offers a wide range of in vitro screens, in vivo DMPK bioanalysis techniques and metabolite analyses services to support the early assessment of compounds, through to regulatory bioanalysis appropriate for submission to authorities.
Our in vitro services include test item characterisation, as well as an evaluation of physiochemical properties, permeability, tissue binding, metabolism, and drug-drug interactions. The ADME team can also support each stage of an in vivo project from inception to final report.
Concept manages established, routine screens with high compound throughput via our liquid handling and automated data management systems. We typically employ protein precipitation for rapid sample processing but are also experienced with more complex sample extraction techniques, such as liquid-liquid extraction, solid phase extraction and chemical derivatisation.