New investigative toxicology research from CXR Biosciences: six posters to be presented at the upcoming Eurotox conference

CXR Biosciences, the investigative toxicology company, is presenting six posters at the upcoming Eurotox meeting in Edinburgh on Monday 8th September.

The research reported in the posters includes:

  • A joint poster with Monsanto, describing studies performed at CXR to determine the mode of action and human relevance of rodent liver tumours.
  • Two posters describing studies performed at CXR to investigate the effects of rodent non-genotoxic carcinogens in CAR knockout and PXR knockout rats.
  • A poster describing the dose-response relationship for phenobarbital-mediated cell proliferation in wild type, humanised PXR-CAR and Pxr-Car knockout mice
  • Investigations with Sanofi-Aventis as to the utility of humanised PXR-CAR-CYP3A4 mice to predict mechanism-based CYP3A4 inhibition in humans
  • The use of everted gut sacs to estimate relative absorption of a structurally-related family of industrial chemicals

For further details, please contact mikepiper@cxrbiosciences.com , or come see us at stand 32 at Eurotox.

The following posters will be presented at Eurotox in Edinburgh on Monday 8th September in Poster Session 1, from 9.30am – 10.30am and 12.30pm to 1.30pm:

Poster Number: P-1.91

Abstract Title: AN EVALUATION OF THE MODE OF ACTION (MOA) AND HUMAN RELEVANCE OF RAT LIVER TUMOURS OBSERVED IN A CHRONIC RAT FEEDING STUDY WITH SILTHIOFAM

Presenting Author: Joel M. Kronenberg, Monsanto

Poster Number: P-1.56

Abstract Title: CHARACTERISATION OF THE HEPATIC EFFECTS OF PHENOBARBITAL (PB) IN CONSTITUTIVE ANDROSTANE RECEPTOR (CAR, NR1I3) KNOCKOUT (KO) RATS

Presenting Author: Mark Chamberlain

Poster Number: P-1.64

Abstract Title: CHARACTERISATION OF THE HEPATIC EFFECTS OF PREGNENOLONE 16 ALPHA-CARBONITRILE (PCN) IN PREGNANE X RECEPTOR (PXR, NR1I2) KNOCKOUT (KO) RATS

Presenting Author: Clifford Elcombe

Poster Number: P-1.65

Abstract Title: DIFFERENTIAL DOSE-RESPONSE RELATIONSHIPS FOR HEPATIC CYP2B10 INDUCTION AND CELL PROLIFERATION IN WILD TYPE MICE AND MICE HUMANIZED (HUPXR/HUCAR) FOR THE CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) AND PREGNANE X RECEPTOR (PXR) ADMINISTERED PHENOBARBITONE (PB)

Presenting Author: Audrey Vardy

Poster Number: P-1.7

Abstract Title: INVESTIGATIONS WITH A HUMANISED CYP3A4/3A7 MOUSE MODEL

Presenting Author: Eddie Doyle

The following poster will be presented at Eurotox in Edinburgh on Monday 8th September in Poster Session 2, from 2.30pm to 4pm:

Number: P-2.105

Abstract Title: THE USE OF EVERTED RAT SMALL INTESTINAL SACS IN VITRO TO ESTIMATE RELATIVE ABSORPTION POTENTIAL OF A SERIES OF ALPHA OLEFINS.

Presenting Author: Robert Powrie

About CXR

Founded in 2001, CXR Biosciences® uses its collaborative approach and toxicological expertise to help customers large and small solve issues relating to the safety of compounds or selection of research candidates. CXR Biosciences® offers tailored preclinical services in the areas of investigative & mechanistic toxicology, exploratory & discovery toxicology and PK & metabolism. Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies.  CXR Biosciences® is located in Dundee, Scotland, United Kingdom.