European Society of Toxicologic Pathology publish conclusions and guidelines on rodent liver hypertrophy

CXR is pleased to announce publication of a review entitled “Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes–Conclusions from the 3rd International ESTP Expert Workshop” in the Journal of Toxicologic Pathology.

CXR Biosciences Research Director, Cliff Elcombe, who was also an European Society of Toxicological Pathology (ESTP) panel member, was involved in the review of adaptive changes in liver hypertrophy (1). The workshop focused its attention on chemicals which induce liver weight increase but are not traditionally associated with acute hepatic necrosis. Published in the Journal of Toxicologic Pathology, the international expert panel concluded that hepatomegaly is considered an adaptive and non-adverse reaction when hepatocellular hypertrophy is observed without the histologic or clinical pathology alterations indicative of liver toxicity.

The panel concluded that:

• The use of cryopreserved human hepatocytes enables reliable data to be obtained on the effects of novel chemicals on enzyme induced drug-metabolism pathways within man.
• The use of humanised mice, which express human nuclear receptors such as PXR, CAR or PPAR, provides comparison data on species-specific responses to prototypic and novel xenobiotics.

The group acknowledged that the development of newer technologies and the use of genetically modified mice have significantly advanced our understanding of the mechanisms involved in nuclear hormone receptor induced hepatocellular hypertrophy.

CXR Biosciences has considerable expertise in understanding the mechanisms of liver hypertrophy, and determining relevance or lack of relevance to humans. For further information, please contact us at info@cxrbiosciences.com.

References:

1)     Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes–Conclusions from the 3rd International ESTP Expert Workshop. A.P. Hall, C. R. Elcombe, J. R. Foster, T. Harada, W. Kaufmann, A. Knipple, K. Kutttler, D. E. Malarkey, R. R. Maronpot, A. Nishikawa, T. Nolte, A. Schulte, V. Strauss and M. J. York (2012) Toxicol Pathol.