CXR Biosciences Ltd and Taconic are pleased to announce the publication of a collaborative study with the Japanese Pharmaceutical company Kyowa Hakko Kirin, demonstrating that the CXR and Taconic humanized mice can be used to predict drug-drug interactions in humans.
Publication in the prestigious Molecular Pharmacology journal is further confirmation of the enthusiasm in academia and industry for more predictive preclinical models, and further demonstrates how these models can be used to better predict drug exposure, distribution, metabolism and safety in humans.
The paper describes transADMET™ mice humanized for the nuclear receptors PXR & CAR and the cytochrome P450 3A4. All three are involved in the metabolism of many marketed drugs, and species differences between the human and animal proteins means that studies in conventional animals may not be predictive of man. The paper, entitled “Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line,” demonstrates that the mice can be used to rank PXR ligands according to their potency to induce CYP3A4 expression in the human liver. Crucially, the mice can also be used to quantitatively predict PXR / CYP3A4-mediated drug-drug interactions in humans.
The hPXR-hCAR-hCYP3A4 mouse is available as part of CXR’s and Taconic’s transADMET™ program. As for all transADMET™ models, the corresponding murine genes have been replaced with their human counterparts. transADMET™ humanized and knockout mice are now available for many of the key genes involved in drug metabolism – for instance PXR, CAR, CYP3A4, CYP2D6, CYP2C9 and MDR1. To enquire about availability and for further details regarding transADMET™ mouse sales, contract services and collaborative research agreements, contact CXR Biosciences by email at transADMET@cxrbiosciences.com or by phone at +44 138 243 2163 or contact Dr. Nico Scheer by email at email@example.com or by phone at +49 221 9645343.
Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Maki Hasegawa, Yury Kapelyukh, Harunobu Tahara, Jost Seibler, Anja Rode, Sylvia Krueger, Dongtao N. Lee, C. Roland Wolf, Nico Scheer. Molecular Pharmacology (2011).
Please click here to access the complete paper and supplementary data.
CXR Biosciences Ltd. is commercializing innovative approaches to transform the drug development and chemical safety assessment process. As well as introducing new technology platforms, CXR also helps customers to take their candidate compounds through development efficiently, or to resolve problems that have been encountered, through the provision of customized solutions. The company has business relationships with many of the world’s leading pharmaceutical companies, chemical companies, biotechnology companies, universities and research institutions. CXR Biosciences Ltd. is located in Dundee, Scotland. More information can be found at http://www.cxrbiosciences.com.
About Kyowa Hakko Kirin
Kyowa Hakko Kirin Co., Ltd. is a Japan-based specialty pharmaceutical company that creates and sales innovative new drugs mainly in the core therapeutic areas of oncology, nephrology, and immunology. Kyowa Hakko Kirin is an R&D-centered company with a strong foundation in biotechnology, particularly state-of-the-art antibody technologies. Kyowa Hakko Kirin strives to contribute to the health and well-being of people around the world.
Taconic is a leading provider of life sciences solutions to researchers worldwide, offering innovative lab animal models and scientific services that facilitate in vivo studies and advance drug discovery. Taconic’s wide range of advanced solutions include custom model design, generation and production, off-the-shelf model repositories, compound profiling, contract research, contract breeding, genetic monitoring and health testing. Headquartered in New York’s Hudson River Valley, Taconic operates seven breeding facilities and three service laboratories in the U.S. and Europe and maintains a staff of over 1,200 scientific specialists committed to technological innovation.
For CXR Biosciences Ltd. media inquiries:
Paul Smith, CEO
+44 1382 432163
For Kyowa Hakko Kirin media inquiries:
Manager, Corporate Communications Dept.
For Taconic media inquiries: