Research carried out at CXR Biosciences, the investigative & exploratory toxicology company, is being presented in a poster at the upcoming Society Of Toxicology (SOT) 2015 annual meeting in San Diego on 22nd – 26th March. The poster, presented by David Farrar of CCERT Ltd, describes investigations into the role of the medium-chain chlorinated paraffin MCCP as an inhibitor of the intestinal absorption of vitamin K.
Using everted gut sacs, it was shown that the presence of MCCP inhibits the absorption of vitamin K, adding further weight to the hypothesis that the preclinical toxicity observed when giving high oral doses of MCCP is due to a reduction in maternal levels of vitamin K, most probably due to an inhibition of its absorption from the GI tract. The work was financially supported by the EuroChlor Chlorinated Paraffins Sector Group.
Further details (poster number, title and authors) are as follows:
1852. The Inhibition of the Intestinal Absorption of Vitamin K by a Medium-Chain Chlorinated Paraffin (MCCP) in an In Vitro Everted Rat Intestinal Sac Model
R. H. Powrie2, C. R. Elcombe2 and D. G. Farrar1.
1 CCERT Ltd, Congleton, United Kingdom and 2 CXR Biosciences Ltd, Dundee, United Kingdom.
For further details, please contact firstname.lastname@example.org, or come see us at stand 1715 at SOT.
Founded in 2001, CXR Biosciences® uses its collaborative approach and toxicological expertise to help customers large and small solve issues relating to the safety of compounds or selection of research candidates. CXR Biosciences® offers tailored preclinical services in the areas of investigative & mechanistic toxicology, exploratory & discovery toxicology and PK & metabolism. Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies. CXR Biosciences® is located in Dundee, Scotland, United Kingdom and is a Scottish Enterprise supported company.