Salt screening

Salt screening is an important part of any drug development programme, both as part of an IP review and to understand the benefits (or otherwise) associated with using different salt forms.

To support the quick movement from early discovery through to first-in-man studies, we have developed a small scale focused salt screen to complement the larger and more exhaustive salt screens which are typically available. This screen looks to produce a limited number of alternative forms quickly and to characterise their performance (solubility, melting point, moisture uptake, structure) in order to provide an optimal (but potentially not final) salt form for the first trial.

In addition to maintaining XRPD, DSC, TGA, DVS and our excipient solubility screen to support that work, we have also teamed up with an industry expert in the field, who provides hands on guidance and consultancy support throughout the programme.

 

 

Supporting Locations