REACH read-across

We have the mechanistic toxicology expertise required to support your REACH read across needs. Where limited animal data exists on a class of structurally-related compounds, it is essential to design and perform short-term, mechanistic studies to support read-across conclusions.  This involves characterising all structurally-related substances in the class for key attributes. This might be absorption and metabolism. This ranking is then used to select a subset of chemicals for further characterisation, for example, additional repeat dose testing or toxicogenomic screening.

Based on such a mechanistic approach, a representative subset of chemicals can be selected for full toxicology testing, rather than every chemical in the class. This approach significantly reduces both test animal numbers and test costs.

Supporting Documents

Supporting Locations