We have the mechanistic toxicology expertise required to support your REACH read across needs. Where limited animal data exists on a class of structurally-related compounds, it is essential to design and perform short-term, mechanistic studies to support read-across conclusions. This involves characterising all structurally-related substances in the class for key attributes. This might be absorption and metabolism. This ranking is then used to select a subset of chemicals for further characterisation, for example, additional repeat dose testing or toxicogenomic screening.
Based on such a mechanistic approach, a representative subset of chemicals can be selected for full toxicology testing, rather than every chemical in the class. This approach significantly reduces both test animal numbers and test costs.