Our primary goal in polymorph screening is typically to identify the most thermodynamically stable polymorph under expected ambient and processing conditions. Getting to that point often requires a structured screen, but tailored to the specific goals of the development team.
The solubility of the compound in each target solvent utilised in the stable polymorph screen is also assessed during this programme. This protocol is supported by the wide range of analytical equipment on site able to quickly characterise the differences between the identified forms (XRPD, FTIR, DSC, TGA, polarised light microscopy, DVS, Raman spectroscopy, Headspace GC and Karl Fischer). Further analytical techniques are then available to determine the solubility/bioavailability of the found forms like low volume dissolution.