in vitro capabilities

Our in-house in vitro capabilities range from permeability and protein binding, metabolism and drug-drug interactions, through to primary cell, cell line, tissue slice and protein based assays.  We have particular expertise in primary cell culture, and in establishing novel cell lines, assays and endpoints to answer specific mechanistic questions

Our full suite of modern laboratory equipment includes two Sciex 6500 triple-quad mass spectrometers, two further triple-quad mass spectrometers, a Xevo G2-XS QTOF/TOF plus a further TOF mass spectrometer. We have the GC, GC-MS and HPLC systems, advanced microscopy and image analysis, a liquid scintillation counter, quantitative PCR and full capability in Agilent gene analysis and Ingenuity bioinformatics.