in vitro absorption

We have the capability to design and run in vitro dermal absorption studies to GLP for agrochemicals, chemicals, consumer products and dermally applied pharmaceuticals. Our dedicated new dermal laboratory is equipped with both static and flow-through diffusion chambers. Human skin is obtained from surgery, with full ethics approval and patient consent, and all skin samples are tested for integrity. Validation data is available on request.

Our dermal services include the following:

  • Designing, running and interpreting dermal absorption studies as part of the risk assessment process (as per oecd test guideline no. 428, and relevant industry guidance if applicable)
  • Custom study design for screening of chemical candidates and/or formulation selection
  • Determination of potential bioequivalence by absorption profile
  • Bioanalysis using labelled or non-labelled test material

Our expert team have many years of industrial experience in:

  • Designing and running dermal absorption studies for agrochemicals, chemicals, consumer products and dermally applied pharmaceuticals
  • Quantitative analysis of biological samples, using labelled methods (e.g. scintillation counting) and non-labelled methods (e.g. lc-ms-ms, gc-ms, hplc-uv). Cxr also has particular expertise in analytical method development, and in the analysis of complex mixtures
  • Generating and applying preclinical data to the risk assessment of agrochemicals, chemicals, pharmaceuticals and consumer products