Regulatory agencies are increasingly concerned about the potential for pesticides and other chemicals to act as endocrine disruptors. Evidence suggests that the endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in growth and reproductive problems. It is therefore suggested that novel chemicals (and those due for re-registration) are tested for their potential to disrupt the human and animal estrogen, androgen and thyroid hormone systems.
We can assess the potential for chemicals to disrupt the endocrine system through in vitro assays. Should the potential for endocrine disruption be observed in a regulatory toxicology study or in vitro assay, we will design an investigative experimental programme to assess the effect of the compound on the endocrine system and determine the potential risk to humans.