Research carried out at CXR Biosciences, the investigative & exploratory toxicology company, is being presented at the upcoming Society Of Toxicology (SOT) 2015 annual meeting in San Diego on 22nd – 26th March. The poster, authored by BASF SE, presents results of mechanistic studies with the imidazole fungicide Prochloraz.
CXR carried out studies in nuclear receptor (PXR and CAR) humanised and knockout mice. Results indicated that, in the absence of Prochloraz-stimulated cell proliferation in the receptor-humanized and receptor-knockout mice, the Prochloraz-induced mouse liver tumors seen in wild-type mice are considered not relevant to humans.
Further details (poster number, title and authors) are as follows:
1634. Mouse Liver Tumors Induced by Prochloraz Have a CAR-Like Mode of Action and Are Not Relevant to Humans
M. Göttel1, S. Melching-Kollmuss1, N. Honarvar2, H. Marxfeld2, C. R. Elcombe3 and I. Fegert1.
1 Regulatory Toxicology Crop Protection, BASF SE, Ludwigshafen, Germany, 2 Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany and 3 CXR Biosciences, Dundee, United Kingdom.
For further details, please contact us, or come see us at stand 1715 at SOT.
Founded in 2001, CXR Biosciences® uses its collaborative approach and toxicological expertise to help customers large and small solve issues relating to the safety of compounds or selection of research candidates. CXR Biosciences® offers tailored preclinical services in the areas of investigative & mechanistic toxicology, exploratory & discovery toxicology and PK & metabolism. Our customers include leading pharmaceutical, agrochemical, chemical, consumer product and biotechnology companies. CXR Biosciences® is located in Dundee, Scotland, United Kingdom and is a Scottish Enterprise supported company.