News

Latest news taken from all the business sites and Group press releases.

Events

Concept Life Sciences group will be attending a number of events and exhibitions throughout the year.

Careers

We employ a diverse and multi-talented workforce from all over the world. Listed below are our current vacancies.

Publications, Posters and Books

We have an outstanding team with a proven track record. They have developed a number of publications, posters and books.

Agenda1
Authors: Bristow, S.C., Shekunov, B.Yu., Tempest-Mitchell, D. and York, P. (2003). Influence of supercritical fluid precipitation process parameters upon drug residual solvent. J. Pharm. Sci. In Press.
Agenda1
Authors: J. Chrom. B. Bristow, S.C., Shekunov, B.Yu., Wrigley, M. and York, P. (2003). Determination of residual N,N-dimethylformamide content in poorly water soluble drugs using headspace gas chromatography. J. Chrom. B. In Press.
Agenda1
Authors: Shekunov, B.Yu., Bristow, S. Chow, A.H.L., Cranswick, L. and Grant, D.J.W. (2003). Formation of solid solutions by precipitation in supercritical CO2. In Press.
Agenda1
Authors: Journal of Supercritical Fluids Bristow, S., Shekunov, T., Shekunov B.Yu. and York P. (2001). Analysis of the supersaturation and precipitation process with supercritical CO2. J. Supercrit. Fluids. 21:257-271.
Agenda1
Authors: Ind. Eng. Chem. Res. 40(7):1732-1739. Bristow, S., Shekunov, B.Yu. and York, P. (2001). Solubility analysis of drug compounds in supercritical carbon dioxide using static and dynamic extraction systems. Ind. Eng. Chem. Res. 40(7):1732-1739.
CXR Biosciences
Authors: Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N
DOI: 10.1124/mol.111.071845
CXR Biosciences
Authors: Elcombe CR, Elcombe BM, Foster JR, Farrar DG, Jung R, Chang S-C, Kennedy GL and L. Butenhoff JL
DOI: 10.1007/s00204-010-0572-2
CXR Biosciences
Authors: Warnasuriya GD, Elcombe BM, Foster J and Elcombe CR
DOI: 10.1007/s00204-009-0489-9
CXR Biosciences
Authors: Skare JA, Hewitt NJ, Doyle E, Powrie R, Elcombe C
DOI: 10.3109/00498250903134443
CXR Biosciences
Authors: Scheer N, Ross J, Kapelyukh Y, Rode A and Wolf CR
DOI: 10.1093/toxsci/kft016
CXR Biosciences
Authors: Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, and Wolf CR
DOI: 10.1172/JCI35483
CXR Biosciences
Authors: Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, Black JR, Elcombe C, Ross JA, Wolf R and Cui W
DOI: 10.1634/stemcells.2007-0718
CXR Biosciences
Authors: Stanley LA, Skare JA, Doyle E, Powrie R, D’Angelo D and Elcombe CR
DOI: 10.1016/j.tox.2005.01.019
CXR Biosciences
Authors: Boverhof DR, Chamberlain MP, Elcombe CR, Gonzalez FJ, Heflich RH, Hernández LG, Jacobs AC, Jacobson-Kram D, Luijten M, Maggi A, Manjanatha MG, Benthem J, Gollapudi BB
DOI: 10.1093/toxsci/kfr075
CXR Biosciences
Authors: Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A and Wolf CR
DOI: 10.1124/mol.111.075192
CXR Biosciences
Authors: Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG
DOI: 10.1093/toxsci/kfu038
CXR Biosciences
Authors: Kerstin Reisingera, Sebastian Hoffmannb, Nathalie Alépéec, Takao Ashikagad, Joao Barrosoe, Cliff Elcombe, Nicola Gellatlyg, Valentina Galbiatih, Susan Gibbsi, Hervé Grouxj, Jalila Hibatallahk, Donald Keller, Petra Kernm, Martina Klarice, Susanne Kollen, Jochen Kuehnlo, Nathalie Lambrechtsp, Malin Lindstedtq, Marion Milletr, Silvia Martinozzi-Teissierc, Andreas Natschs, Dirk Petersohna, Ian Piket, Hitoshi Sakaguchiu, Andreas Schepkyo, Magalie Tailhardatv
DOI: 10.1016/j.tiv.2014.10.018
CXR Biosciences
Authors: Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M
DOI: 10.1093/toxsci/kfu099
CXR Biosciences
Authors: Matthew J. LeBaron, David R. Geter, Reza J. Rasoulpour, B. Bhaskar Gollapudi, Johnson Thomas, Jennifer Murray, H. Lynn Kan, Amanda J. Wood, Cliff Elcombe, Audrey Vardy, Jillian McEwan, Claire Terry, Richard Billington
DOI: doi:10.1016/j.taap.2013.04.009
CXR Biosciences
Authors: Plummer S., Dan D., Quinney J., Hallmark N., Phillips RD., Millar M., Macpherson S., Elcombe CR
DOI: 10.1093/toxsci/kft016
CXR Biosciences
Authors: Elcombe C., Peffer R., Wolf D., Bailey J., Bars R., Bell D., Cattley R., Ferguson S., Geter D., Goetz A., Goodman J., Hester S., Jacobs A., Omiecinski C., Schoeny R., Xie W., Lake B
DOI: 10.3109/10408444.2013.835786
CXR Biosciences
Authors: Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio, Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG
DOI: 10.1093/toxsci/kfs303
CXR Biosciences
Authors: Elcombe CR, Elcombe BM, Foster JR, Chang S-C, Ehresmanc DJ, Noker PE and Butenhoff JL
DOI: 10.1016/j.tox.2011.12.015
CXR Biosciences
Authors: Donaldson K., Schinwald A., Murphy F., Cho W.S., Duffin R., Tran L., Poland C
DOI: 10.1021/ar300092y
CXR Biosciences
Authors: A.P. Hall, C. R. Elcombe, J. R. Foster, T. Harada, W. Kaufmann, A. Knipple, K. Kutttler, D. E. Malarkey, R. R. Maronpot, A. Nishikawa, T. Nolte, A. Schulte, V. Strauss and M. J. York
DOI: 10.1177/0192623312448935
CXR Biosciences
Authors: N. Scheer, P. Balimane, M.D. Hayward, S. Buechel, G. Kauselmann, C.R Wolf
DOI: 10.1124/dmd.112.047605
CXR Biosciences
Authors: N. Scheer, Y. Kapelyukh, L. Chatham, A. Rode, S. Buechel, C.R. Wolf
CXR Biosciences
Authors: Seacat AM, Thomford PJ, Hansen KJ, Clemen LA, Eldridge SR, Elcombe CR and John L. Butenhoff
DOI: 10.1016/S0300-483X(02)00511-5
CXR Biosciences
Authors: Butenhoff J, Costa G, Elcombe C, Farrar D, Hansen C, Iwai H, Jung R, Kennedy G, Lieder P, Olsen G and Thomford P
DOI: 10.1093/toxsci/69.1.244
Peakdale Molecular
Authors: P Wainwright et al. Synlett 2011, no. 13, pp 1900-1904
DOI: DOI: 10.1055/s-0030-1260943
Peakdale Molecular
Authors: D.C. Pryde et al. Tet. Lett. 2011, Vol. 52, Iss. 48, pp 6415-6419
DOI: DOI: 10.1016/j.tetlet.2011.09.074
Peakdale Molecular
Authors: M. Betson et al, Organic and Biomolecular Chemistry, 2014, vol 12, issue 46, pp 9291-9306
DOI: 10.1039/C4OB01449A
Peakdale Molecular
Authors: C. Chapron et al, Bioorg. and Med. Chem. Lett., 2014, vol 24, issue 12, pp2699-2702
DOI: DOI: 10.1016/j.bmcl.2014.04.050
Peakdale Molecular
Authors: P. Wainwright et al, Nucleosides, Nucleotides and Nucleic Acids, vol 32, issue 9, pp477-492P. Wainwright et al, Nucleosides, Nucleotides and Nucleic Acids, vol 32, issue 9, pp477-492
DOI: 10.1080/15257770.2013.820833
Peakdale Molecular
Authors: P. Wainwright et al. SYNLETT 2005, No. 5, pp 0765-0768
DOI: DOI: 10.1055/s-2005-863745
Peakdale Molecular
Authors: A. Maddaford et al. SYNLETT 2007, No. 20, pp 3149-3154
DOI: DOI: 10.1055/s-2007-1000822
Peakdale Molecular
Authors: A. Maddaford et al. SYNTHESIS 2007, No. 9, pp 1378-1384
DOI: DOI: 10.1055/s-2007-966009
Peakdale Molecular
Authors: Berry, J. M., Doyle, P. M., & Young, D. W. (2005)
Peakdale Molecular
Authors: Davies, D. E., Doyle, P. M., Hill, R. D. & Young, D. W. (2005)
Peakdale Molecular
Authors: Davies, D. E., Doyle, P. M., Farrant, R. D., Hill, R. D., Hitchcock, P. B., Sanderson, P. N. & Young, D. W. (2003)
Peakdale Molecular
Authors: Lindon, J. C., Farrant, R. D., Sanderson, P. N., Doyle, P. M., Gough, S. L., Spraul, M., Hofmann, M. & Nicholson, J. K., (1995)
Peakdale Molecular
Authors: Dinsmore, A., Doyle, P. M. & Young, D. W., (1995)
Peakdale Molecular
Authors: Sanderson, P. N., Glen, R. C., Payne, A. W. R., Heide, C., Hudson, B. D., Tranter, G. E., Doyle, P. M. & Harris, C. J., (1994)
Peakdale Molecular
Authors: Wisskirchen, F. M., Doyle, P. M., Gough, S. L., Harris, C. J. & Marshall, I., (1994),
Peakdale Molecular
Authors: Humphries, M. J., Doyle, P. M. & Harris, C. J., (1994)
Peakdale Molecular
Authors: Sanderson, P. N., Glen, R. C., Heide, C., Hudson, B. D., Tranter, G. E., Doyle, P. M. & Harris, C. J., (1993)
Peakdale Molecular
Authors: August, R. A., Bowler, A. N., Doyle, P. M., Durand, X. J., Hudhomme, P., Kahn, J. A., Moody, C. M. & Young, D. W., (1992)
Peakdale Molecular
Authors: Avent, A. G., Bowler, A. N., Doyle, P. M., Marchand, C. M. & Young, D. W., (1992)
Peakdale Molecular
Authors: Ford, A. J., Green, D. J., Doyle, P. M., Stone, D. & Longridge, D. J., (1991)
Peakdale Molecular
Authors: Bowler, A. N., Doyle, P. M., Hitchcock, P. B. & Young, D. W., (1991)
Peakdale Molecular
Authors: Young, D. W., Bowler, A. N. & Doyle, P. M., (1991)
Peakdale Molecular
Authors: Wisskirchen, F. M., Doyle, P. M., Gough, S. L., Harris, C. J. & Marshall, I., (1999)
Peakdale Molecular
Authors: Doyle, P. M., Harris, C. J., Carter, K. R., Simpkin, D. S. A., Bailey-Smith, P., Stone, D., Russell, L. & Blackwell, G. J., (1990)
Peakdale Molecular
Authors: Ialenti, A., Doyle, P. M., Hardy, G. W., Simpkin, D. S. A. & DiRosa, M., (1990)
Peakdale Molecular
Authors: Hardy, G. W., Doyle, P. M. & Smith, T. W., (1987)
Peakdale Molecular
Authors: Bowman, P. J., Brown, B. R., Chapman, M. A. & Doyle, P. M., (1984)
Peakdale Molecular
Authors: Doyle, P. M., (1995)
Peakdale Molecular
Authors: Jones, D. T., Moody, C. M., Uppenbrink, J., Viles, J. H., Doyle, P. M., Harris, C. J., Pearl, L. H., Sadler, P. J. & Thornton, J. M., (1996)
Peakdale Molecular
Authors: Berry, J. M., Doyle, P. M., & Young, D. W. (2002)
Peakdale Molecular
Authors: Dinsmore, A., Doyle, P. M., Steiger, M. & Young, D. W. (2002)
Peakdale Molecular
Authors: Dinsmore, A., Doyle, P. M. & Young, D. W. (2002)
Peakdale Molecular
Authors: Dinsmore, A., Doyle, P. M., Hitchcock, P. B. & Young, D. W. (2000)
Peakdale Molecular
Authors: Barker, E., Doyle P. M., Hopkins, S. & Rose V. S., (1999)
Peakdale Molecular
Authors: Barker, E., Doyle P. M., Harris, C. J. & Slater, M. J., (1998)
Peakdale Molecular
Authors: Viles, J. H., Patel, S. U., Mitchell, J. B. O., Moody, C. M., Justice, D. E., Uppenbrink, J., Doyle, P. M., Harris, C. J., Sadler, P. J. & Thornton, J. M. (1998)
Peakdale Molecular
Authors: Bowler, A. N., Doyle, P. M., Hitchcock, P. B. & Young, D. W. (1997),
Peakdale Molecular
Authors: Bowler, A. N., Dinsmore, A., Doyle, P. M. & Young, D. W. (1997)
Peakdale Molecular
Authors: Wisskirchen, F. M., Doyle, P. M., Gough, S. L., Harris, C. J. & Marshall, I., (1996)
Peakdale Molecular
Authors: Viles, J. H., Mitchell, J. B. O., Gough, S. L., Doyle, P. M., Harris, C. J., Sadler, P. J. & Thornton, J. M. (1996)
Peakdale Molecular
Authors: Viles, J. H., Uppenbrink, J., Moody, C. M., Sims, M., Doyle, P. M., Harris, C. J., Sadler, P. J. & Thornton, J. M. (1996)
Peakdale Molecular
Authors: Doyle, P. M., Harris, C. J., Moody, C. M., Sadler, P. J., Sims, M., Thornton, J. M., Uppenbrink, J. & Viles, J. H, (1996)
Peakdale Molecular
Authors: Doyle, P. M., Szakolkai, A. & Young, D. W., (1983)

Books

Synthetic Methods in Drug Discovery ( RSC, Vol 1 & 2)
Edited David C Blakemore, Paul M Doyle and Yvette M Fobian ( May 2016)

Posters

4th European Conference of the Medicinal Chemistry Group of the Atlantic Arc in Angers (1995)
Berry, J. M., Young, D, W. & Doyle, P. M., “Synthesis of β-turn Mimetics”

Perspectives on Protein Engineering, Bath September 1995
Mitchell, J. B. O., Viles, J. H., Thornton, J. M., Sadler, P. J., Gough, S. L., Moody, C. M., Doyle, P. M. & Harris, C. J., “Cyclic Pentapeptide Structures”
Viles, J. H., Doyle, P. M., Harris, C. J., Moody, C. M., Sadler, P. J., Sims, M., Thornton, J. M. & Uppenbrink, J., “Biologically Active Conformation of an LDV Peptide Induced by the Incorporation of a Type II’ β-turn Mimetic”
Doyle, P. M., Harris, C. J., Justice, D. E. & Moody, C. M., “The Synthesis of Zinc Finger Peptides and Cyclic Hexapeptides Containing Structural Mimetics”

Hit Finding Libraries, San Diego 2004
GPCR Family B Libraries
Ion Channel Libraries

Mouse Liver Tumors Induced by Prochloraz Have a CAR-Like Mode of Action and Are Not Relevant to Humans. This poster was presented at SOT 2015 with BASF SE

The Inhibition of the Intestinal Absorption of Vitamin K by a Medium-Chain Chlorinated Paraffin (MCCP) in an In Vitro Everted Rat Intestinal Sac Model. This poster was presented at SOT 2015 with CCERT Ltd

Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats. This poster was presented at Eurotox 2014

Characterisation of the hepatic effects of pregnenolone 16a- carbonitrile (PCN) in Pregnane X Receptor (PXR, NR1I2) knockout rats. This poster was presented at Eurotox 2014

Differential Dose-Response Relationships For Hepatic Cyp2b10 Induction And Cell Proliferation In Wild Type Mice And Mice Humanised (huPXR/huCAR) For The Constitutive Androstane Receptor (CAR) And Pregnane X Receptor (PXR) Administered Phenobarbitone (PB). This poster was presented at Eurotox 2014

The use of everted rat small intestinal sacs in vitro to estimate relative absorption potential of a series of alpha olefins. This poster was presented at Eurotox 2014

Investigations with a humanised CYP3A4/3A7 mouse model. This poster was presented at Eurotox 2014

An evaluation of the mode of action(MOA) and human relavance of rat liver tumours oserved in a chronic rat feeding study with silthiofam. This poster was presented at Eurotox 2014 with Monsanto

Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats. This poster was presented at SOT 2014

The Use Of An Oxidative Stress Associated in vitro Screen For The Prediction Of Potential Nanoparticle Toxicity. The poster was presented at Nanomedicine 2013

Immunohistochemical and ChIP microarray analysis of peroxisome proliferator activated receptor alpha (PPARa) in fetal rat testes exposed in utero to dibutylphthalate. This poster was presented at SOT 2011.

An investigation of the clearance of 14-C labelled vitamin K in control and MCCP-treated female CD rats. This poster was presented at SOT 2011.

The effects of tris (2-ethylhexyl) trimellitate (TOTM) on gene expression associated with testicular mal-development (TMD) in rat foetal testes. This poster was presented at SOT 2011.

Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms

An In vitro Model for the Prediction of Chemical Metabolism and Toxicity

In vitro screening of a series of fluoropropenes and fluorocyclopropenes for hepatic s-glutathione conjugation and NADPH dependent oxidation. This poster was presented at the International Congress of Toxicology, Montreal, 2007

Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action. This poster was presented at the British Toxicology Society Perfluorooctanoic Acid Workshop, 5th-6th November 2007

Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment. This poster was presented at the Toxicogenomics Meeting, Nice, 1st October 2007

Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO) This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007

Characterisation of APFO Induced Hepatomegaly in Rats This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007

In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Identification of region specific gene expression changes and signalling pathways affected by Di-butyl-phthalate in foetal rat testes This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007

Medium-chain chlorinated paraffin (MCCP)-induced haemorrhagic lesions in neonatal Sprague-Dawley rats. A role for altered vitamin K disposition? Society of Toxicology 2005

The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats

High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail

Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine

Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis