Latest news taken from all the business sites and Group press releases.
Concept Life Sciences group will be attending a number of events and exhibitions throughout the year.
We employ a diverse and multi-talented workforce from all over the world. Listed below are our current vacancies.
Publications, Posters and Books
We have an outstanding team with a proven track record. They have developed a number of publications, posters and books.
Synthetic Methods in Drug Discovery ( RSC, Vol 1 & 2)
Edited David C Blakemore, Paul M Doyle and Yvette M Fobian ( May 2016)
4th European Conference of the Medicinal Chemistry Group of the Atlantic Arc in Angers (1995)
Berry, J. M., Young, D, W. & Doyle, P. M., “Synthesis of β-turn Mimetics”
Perspectives on Protein Engineering, Bath September 1995
Mitchell, J. B. O., Viles, J. H., Thornton, J. M., Sadler, P. J., Gough, S. L., Moody, C. M., Doyle, P. M. & Harris, C. J., “Cyclic Pentapeptide Structures”
Viles, J. H., Doyle, P. M., Harris, C. J., Moody, C. M., Sadler, P. J., Sims, M., Thornton, J. M. & Uppenbrink, J., “Biologically Active Conformation of an LDV Peptide Induced by the Incorporation of a Type II’ β-turn Mimetic”
Doyle, P. M., Harris, C. J., Justice, D. E. & Moody, C. M., “The Synthesis of Zinc Finger Peptides and Cyclic Hexapeptides Containing Structural Mimetics”
Hit Finding Libraries, San Diego 2004
GPCR Family B Libraries
Ion Channel Libraries
Mouse Liver Tumors Induced by Prochloraz Have a CAR-Like Mode of Action and Are Not Relevant to Humans. This poster was presented at SOT 2015 with BASF SE
The Inhibition of the Intestinal Absorption of Vitamin K by a Medium-Chain Chlorinated Paraffin (MCCP) in an In Vitro Everted Rat Intestinal Sac Model. This poster was presented at SOT 2015 with CCERT Ltd
Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats. This poster was presented at Eurotox 2014
Characterisation of the hepatic effects of pregnenolone 16a- carbonitrile (PCN) in Pregnane X Receptor (PXR, NR1I2) knockout rats. This poster was presented at Eurotox 2014
Differential Dose-Response Relationships For Hepatic Cyp2b10 Induction And Cell Proliferation In Wild Type Mice And Mice Humanised (huPXR/huCAR) For The Constitutive Androstane Receptor (CAR) And Pregnane X Receptor (PXR) Administered Phenobarbitone (PB). This poster was presented at Eurotox 2014
The use of everted rat small intestinal sacs in vitro to estimate relative absorption potential of a series of alpha olefins. This poster was presented at Eurotox 2014
Investigations with a humanised CYP3A4/3A7 mouse model. This poster was presented at Eurotox 2014
An evaluation of the mode of action(MOA) and human relavance of rat liver tumours oserved in a chronic rat feeding study with silthiofam. This poster was presented at Eurotox 2014 with Monsanto
Characterisation of the hepatic effects of phenobarbital in Constitutive Androstane Receptor (CAR, NR1I3) knockout rats. This poster was presented at SOT 2014
The Use Of An Oxidative Stress Associated in vitro Screen For The Prediction Of Potential Nanoparticle Toxicity. The poster was presented at Nanomedicine 2013
Immunohistochemical and ChIP microarray analysis of peroxisome proliferator activated receptor alpha (PPARa) in fetal rat testes exposed in utero to dibutylphthalate. This poster was presented at SOT 2011.
An investigation of the clearance of 14-C labelled vitamin K in control and MCCP-treated female CD rats. This poster was presented at SOT 2011.
The effects of tris (2-ethylhexyl) trimellitate (TOTM) on gene expression associated with testicular mal-development (TMD) in rat foetal testes. This poster was presented at SOT 2011.
Transcript Profiling of PXR and CAR Knock-out and Humanized Mouse Liver Provides Insight into Endogenous Roles of the Human PXR/CAR Isoforms
An In vitro Model for the Prediction of Chemical Metabolism and Toxicity
In vitro screening of a series of fluoropropenes and fluorocyclopropenes for hepatic s-glutathione conjugation and NADPH dependent oxidation. This poster was presented at the International Congress of Toxicology, Montreal, 2007
Overview of Mechanistic Research on Perfluorinated Alkyl Acids with Emphasis on the Potential Value of New Technologies and Bio-Informatics in Elucidating Modes of Action. This poster was presented at the British Toxicology Society Perfluorooctanoic Acid Workshop, 5th-6th November 2007
Laser Microdissection Targetted Transcription profiling and Pathways Analysis for Mechanism Based Hazard Assessment. This poster was presented at the Toxicogenomics Meeting, Nice, 1st October 2007
Comparison of Gene Expression Changes in Whole Pancreas With Isolated Pancreatic acinar cells of rats fed diets containing Wyeth 14,643 or Ammonium Perfluorooctanoate (APFO) This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007
Characterisation of APFO Induced Hepatomegaly in Rats This poster was presented at the British Toxiocology Society Annual Congress, 15-18th April 2007
In vitro metabolites of Arylamine hair dyes in human hepatic microsomes and human hepatocyte This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007
Comparison of 1-colour and 2-colour methods for microarray-based transcription profiling analysis with laser captured micro-dissected analysis This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007
Identification of region specific gene expression changes and signalling pathways affected by Di-butyl-phthalate in foetal rat testes This poster was presented at Society of Toxicology, 46th Annual Meeting and Tox Expo, 25-29th March 2007
Medium-chain chlorinated paraffin (MCCP)-induced haemorrhagic lesions in neonatal Sprague-Dawley rats. A role for altered vitamin K disposition? Society of Toxicology 2005
The Effects of Ammonium Perfluorooctanoate (APFO) on the Transcriptional Profile of Pancreas and Liver of Male Rats
High Throughput Inhibition Screening of Five Major Human cytochrome P450 Enzymes using an In vitro Substrate cocktail
Hepatic Metabolism of Aromatic Amine Hair Dye Components as Compared with that of 2-Aminofluorine
Different Effects of PPAR alpha and PPAR gamma Agonists on Hepatocytes S-phase and Apoptosis